Results 91 to 100 of about 218,024 (323)
, 2018 In this paper, the authors examine what coaching supervision is, particularly the developmental function and how it compares with a coaching relationship for a coach.
Merrick, Lis, Stokes, Paul
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Using Fuzzy Logic to Evaluate Normalization Completeness for An Improved Database Design
, 2012 A new approach, to measure normalization completeness for conceptual model, is introduced using quantitative fuzzy functionality in this paper. We measure the normalization completeness of the conceptual model in two steps.
Iqbal, Nayyar +2 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Metodologija za objektne kataloge [PDF]
Geodetski Vestnik, 2002 This paper first describes the significance and role of the unifiedmethodology for object cataloguing. Object catalogues should becomeconformable to the international standard ISO 19110 GI - Featurecataloguing methodology, which was developed, among ...
Radoš Šumrada
doaj
A natural cure for the pet fish problem: feature emergence as classificatory composition [PDF]
, 2013 Where do emergent features come from? This has long been an intriging puzzle. The concept of pet fish illustrates the difficulty. Most people expect pet fish to live in bowls, even though this is not something either pets or fish normally do.
Thornton, Chris
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Schema Understandability: A Comprehensive Empirical Study of Requirements Metrics
InformationEnsuring high-quality data warehouses is crucial for organizations, as they provide the reliable information needed for informed decision-making. While various methodologies emphasize the importance of requirements, conceptual, logical, and physical ...
Tanu Singh +3 more
doaj +1 more source