Results 51 to 60 of about 26,231 (243)
Miscelánea: A Journal of English and American Studies, 1997 Taking as bases the well-known idea that in Cognitive Semantics metaphor, a conceptual rather than a linguistic phenomenon, is considered to be a series of conceptual mappings from a source to a target domain ( cfr.
María Sandra Peña Cervel
doaj +1 more source
Journal of King Saud University: Computer and Information Sciences, 2020 In software modeling, UML (Unified modeling language) receives increasing attention from designers of real-time systems in software development. The emergence of temporal database calls for new visual and efficient modeling techniques to facilitate the ...
Soumiya Ain El Hayat +2 more
doaj +1 more source
Image Schemas and Conceptual Blending in Diagrammatic Reasoning: The Case of Hasse Diagrams [PDF]
, 2021 Dimitra Bourou +2 more
openalex +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
An Overview of the Network of Meanings of the Prepositions “Ala” in the Quran With the Cognitive Approach [PDF]
آموزههای قرآنی, 2019 The word “Ala” is one of the Arabic prepositions used in many cases in the Quran. This in the sense of its proto-scene encodes the concept of transcendence. But all the uses of this term in the Qur'an are not limited to this proto-scene meaning.
Maryam Tavakolnia, Valiollah Hasoumi
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Cuadernos de Investigación Filológica, 2013 This paper addresses the issue of the organization of (propositional) knowledge in the form of conceptual networks. We follow closely Ruiz de Mendoza’s (1996) proposal in this respect and we try to make it compatible with the still programmatic proposals
Francisco José Ruiz de Mendoza Ibáñez +1 more
doaj +1 more source