Results 71 to 80 of about 218,024 (323)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Early maladaptive schemas from child maltreatment in depression and psychotherapeutic remediation: a predictive coding framework

Frontiers in Psychiatry
Schemas are affective-cognitive conceptual models of self, others and the world, derived from life experience. Predictive Coding theory proposes schema are created from perceptual input as follows: Based on previous similar experiences, the brain ...
Gita Ramamurthy, Alan Chen
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

UML/OCL based design and the transition towards temporal object relational database with bitemporal data

Journal of King Saud University: Computer and Information Sciences, 2020
In software modeling, UML (Unified modeling language) receives increasing attention from designers of real-time systems in software development. The emergence of temporal database calls for new visual and efficient modeling techniques to facilitate the ...
Soumiya Ain El Hayat, Fouad Toufik, Mohamed Bahaj   +2 more
doaj   +1 more source

Developing Translation Rules for Converting Relational to Object Oriented Database Conceptual Schema [PDF]

, 2005
A multidatabase is a confederation of pre-existing distributed, heterogeneous, and autonomous database system. Obviously, the integration process is essential in the effort of forming a distributed, heterogeneous database system.
Ibrahim, Hamidah, Ki, Soon Lay, Mamat, Ali, Muda, Zaiton   +3 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Schema-Based Instruction an Effective Approach to Word Problem Solving in Students with Specific Learning Disorders: A Review Study

پژوهان, 2021
Background and Objective: Today, different teaching approaches have been offered to solve word problems. Schema-based instruction is one of these new approaches.
Rahim Badri, Shahrooz Nemati, Tooraj Hashemi, Omid Ebrahimi   +3 more
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Role of the Event Structure Metaphot and of Image-Schematic Structure in Metaphors for Happiness and Sadness

Miscelánea: A Journal of English and American Studies, 1997
Taking as bases the well-known idea that in Cognitive Semantics metaphor, a conceptual rather than a linguistic phenomenon, is considered to be a series of conceptual mappings from a source to a target domain ( cfr.
María Sandra Peña Cervel
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source