Results 141 to 150 of about 7,797,471 (373)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Penerapan Metode Peer Tutoring untuk Meningkatkan Pemahaman Konsep Materi Perkalian Bersusun Pada Siswa Kelas III SD

open access: yesScholaria: Jurnal Pendidikan dan Kebudayaan, 2018
In learning Mathematics, conceptual understanding is a primary competency that the students must acquire, because through understanding the concept the students would understand what is being learned and are able to apply them thus they can pursue ...
Jhon Tetiwar, Oce Datu Appulembang
doaj  

Enhancing Students' Conceptual Understanding of Newton Law with Conceptual Problem Solving Learning: An Experimental Study

open access: yesInternational Journal of Education and Teaching Zone
This study aims to examine the effectiveness of Conceptual Problem Solving-based learning in improving student conceptual understanding of Newtonian mechanics.
Tsania Nur Diyana, Sutopo Sutopo
doaj   +1 more source

Kinematics Conceptual Understanding: Interpretation of Position Equations as a Function of Time

open access: yesJurnal Pendidikan Sains, 2019
: This article aims at describing the ability of 48 students of physics education in determining distance traveled, average speed, and acceleration of position functions.
Muhammad Reyza Arief Taqwa, Lugy Rivaldo
doaj   +1 more source

A CURE on the Evolution of Antibiotic Resistance in Escherichia coli Improves Student Conceptual Understanding. [PDF]

open access: yesCBE Life Sci Educ, 2023
Freeman S   +16 more
europepmc   +1 more source

Understanding SOA Migration Using a Conceptual Framework [PDF]

open access: yes, 2010
Migration of legacy assets to SOA embodies a key software engineering challenge. Over a decade there has been an increasing interest in the approaches addressing SOA migration.
Lago, P., Razavian, M.
core   +3 more sources

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