Results 191 to 200 of about 7,797,471 (373)

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Development of interactive learning media assisted by scratch to enhance understanding of rectangle and square concepts

Research and Development in Education
The rapid development of technology sparks an increase in educational innovations, one of which is the use of interactive learning media. Interactive learning media is a tool to gradually improves the delivery of mathematics learning materials.
Lioni Anka Monalisa, Arika Indah Kristiana, Arif Fatahillah, Edy Wihardjo, Valydhifa Ailly Aulia, Saddam Hussen, Oluwanife Segun Falebita   +6 more
doaj   +1 more source

A chain-interactive innovation model for the learning economy: Prelude for a proposal [PDF]

The implementation of innovation has a central role in the dynamic knowledge economy of the twenty-first century. The ability to assemble new expertise and commercialise new business propositions constitutes one of the central characteristics in today’s ...
João Caraça, João Lobo Ferreira, Sandro Mendonça   +2 more
core  

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

The Effects of the Laboratory on College Students' Understanding of Evolution: Implications for Conceptual Change.

, 2000
Lorna Holtman
openalex   +2 more sources

Assessing Students’ Conceptual Understanding in Science: An introduction about a national project in Taiwan [PDF]

, 2007
Mei‐Hung Chiu, Chorng‐Jee Guo, David F. Treagust   +2 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Can children construct inverse relations in arithmetic? Evidence for individual differences in the development of conceptual understanding and computational skill [PDF]

, 2007
Camilla Gilmore, Peter Bryant
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Current Conceptual Understanding of the Epileptogenic Network From Stereoelectroencephalography-Based Connectivity Inferences. [PDF]

Front Neurol, 2020
Gupta K, Grover P, Abel TJ.
europepmc   +1 more source