Results 211 to 220 of about 2,211,033 (313)

RV-LV volumetric relationship during graded supine exercise in healthy adults assessed by cardiovascular magnetic resonance. [PDF]

Physiol Rep
Ikeda M, Hieda M, Yoshida K, Imabayashi M, Toyomura D, Izumi R, Nishizaki A, Wada T, Saito Y, Tokunaga C, Nishikawa K, Kurokawa S, Fukudome Y, Hino T, Yamasaki Y, Hosokawa K, Fukata M, Ishigami K, Abe K, Akashi K.   +19 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Rescue therapy of paediatric lupus nephritis with plasma cell-directed antibodies. [PDF]

Ann Rheum Dis
Kasinathan S, Balboni IM, Hsu J, Grimm PC, Yeung J, Jackson SW, Robinson WH, Moyer A, Bertaina A, Alexander JL, Profita EL, Lee J, Satpathy AT, Grieshaber-Bouyer R, Pooni R.   +14 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Canadian healthcare professionals' attitudes towards climate change and the environmental impact of inhalers. [PDF]

J Clim Chang Health
Butler SJ, Digby GC, Roy C, Tse SM, Sajwani S, Hubick J, McCoy C, Lam I, Singer A, Kaplan A, Leek E, Walji S, Stoynova V, Penz E, Gupta S.   +14 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Understanding the interplay between cognitive changes at menopause, the workplace, and mental health: qualitative findings from the MARIE-UK (WP2a) project. [PDF]

Front Glob Womens Health
Hinchliff S, Potočnik K, Delanerolle G, Taylor J, Elliot K, Fontana D, Saraswat L, Panay N, Talaulikar V, Atkinson C, Kemp HF, Kurmi O, Rathnayake N, Al-Kharusi L, Pathiraja V, Al-Riyami N, Palanisamy R, Eleje GU, Phiri P.   +18 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source