Results 91 to 100 of about 3,278 (260)

ORGANIZATIONAL AND REGULATORY FRAMEWORK OF PUBLIC-PRIVATE PARTNERSHIP

RUDN Journal of Public Administration, 2015
The article discusses the new perspectives of realization of social projects on mutually beneficial terms with the public-private partnership mechanisms and its basic types.
Vladimir A Fedorov, Victoria A Martynova
doaj  

Application of Public-Private Partnership Mechanisms to Ensure Innovative Development of the Healthcare Sector

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The pursuit of technological sovereignty in the current geopolitical situation has led to a growing emphasis on studying relations in the field of government support for healthcare innovation, in particular, the institute of public–private ...
D. V. Balandin, D. I. Fedorova
doaj   +1 more source

LEGAL NATURE AND CONTENT OF THE CONCESSION AGREEMENT

Bulletin of the South Ural State University series "Law"
The author convincingly proves that the concession agreement is a named (independent) civil law contract. This agreement has a detailed, detailed legal regulation. A concession agreement can be qualified as a complex agreement, since it is a complex structural (multicomponent) agreement.
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Založno pravo na koncesiji na pomorskom dobru

Poredbeno Pomorsko Pravo, 2009
Razvoj bilo kojeg većeg projekta na pomorskom dobru u Republici Hrvatskoj bez bankarskih financiranja praktički je nemoguće. Budući da se takvi komercijalni projekti mogu realizirati jedino putem koncesije, te imajući u vidu da na pomorskom dobru nije
Zoran Tasić
doaj  

Factors’ Influence on Human–Computer Negotiation Results—A Systematic Evaluation

Applied Sciences
Artificial intelligence (AI) and computer agents are increasingly shaping daily decision-making and commercial interactions. This study investigates the influence of computer agents’ attributes on negotiation results and proposed a systematic method to ...
Yushan Liu, Rustam Vahidov, Raafat Saade
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

THE CONCESSION AGREEMENT AS A SPECIES OF THE DISTRIBUTION CONTRACT

, 2018
The present work applied the methodology of the bibliographic research associated with a deductive method. Business relations are usually governed by contracts. Some contracts, by their object, are typical and unique without it unfolding other businesses, such as buying and selling for example. The automotive distribution agreement under Law 6,729 / 79
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source