Results 51 to 60 of about 2,163,668 (282)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Towards concessions 2.0 in Central Africa. Managing overlapping rights between industrial concessions and community forestry [PDF]
, 2016 In Central Africa, industrial forest concessions and protected areas occupy most of the forested space while community forests are confined to the margins.
Karsenty, Alain, Vermeulen, Cédric
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
The Balance of Concessions in Trade Agreements
SSRN Electronic JournalThis paper introduces a quantitative framework to analyze the WTO’s reciprocity principle. Utilizing two polar bargaining environments, we measure terms-of-trade concessions among WTO members and examine how shifts in applied tariffs and economic fundamentals affect bilateral and multilateral balance of concessions. We find significant disparities in
BESHKAR, Mostafa +2 more
openaire +1 more source
Private Roads, Public Costs: The Facts About Toll Road Privatization and How to Protect the Public [PDF]
, 2009 Provides an overview of trends in toll road privatization and discusses implications for the public, including loss of control, financial risk, and lack of transparency.
Kari Wohlschlegel +2 more
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Privatization and the Public Interest: The Need for Transparency and Accountability in Chicago's Public Asset Lease Deals [PDF]
, 2009 Examines the appeal and risks of infrastructure privatization and Chicago's history with privatization deals. Recommends public interest principles for future deals, rules and processes for vetting proposals, and a commitment to government ...
Brian Imus +2 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
About key deficiencies legislation on concession agreements
Russian competition law and economy, 2018 The article gives a critical analysis of the shortcomings of the Federal Law of July 21,2005 No. 115-FZ "On concession agreements" in comparison with the comparable provi- sions of Federal Law No. 44-FZ of 05.04.2013 "On the contract system in the procure- ment of goods, works, services to ensure state and municipal needs ", taking into account the ...
openaire +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source