Results 51 to 60 of about 3,278 (260)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Competition in the “Deutschlandtakt”

open access: yesWirtschaftsdienst, 2022
The new federal government has retained the transport policy goal of increasing rail traffic. In its 24 November 2021 agreement, the coalition confirmed further investments in rail infrastructure.
Jürgen Kühling, Katja Greer
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

DEVELOPMENT OF THE NETWORK OF SOCIAL SHOPS BASED ON FRANCHISE

open access: yesВестник университета, 2018
Franchising is a long-term commercial concession agreement between companies, implying the transfer by one company of another of its right to use certain intellectual property objects within the specified territory.
D. Wafin, E. Hmelchenko
doaj   +1 more source

THE AGREEMENT FOR THE CONCESSION OF PUBLIC ASSETS IN THE LIGHT OF THE ADMINISTRATIVE CODE [PDF]

open access: yesChallenges of the Knowledge Society, 2022
As of 5 July 2019, the content of the essential normative act in the field of public administration in our country, namely the Administrative Code has been regulated the legal regime of the public and private property of the state and of the ...
Elena Emilia ȘTEFAN
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Actual Problems and Prospects for the Development of Public-Private Partnership in Russia

open access: yesУправленческое консультирование, 2018
Russia is currently experiencing investment hunger, and the Russian economy is largely not to be invested. Public-private partnerships can serve as the main direction of the investment of the Russian economy.
Anatoly Yakovlevich Zaporozhan
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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