Results 51 to 60 of about 3,278 (260)
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Competition in the “Deutschlandtakt”
The new federal government has retained the transport policy goal of increasing rail traffic. In its 24 November 2021 agreement, the coalition confirmed further investments in rail infrastructure.
Jürgen Kühling, Katja Greer
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
DEVELOPMENT OF THE NETWORK OF SOCIAL SHOPS BASED ON FRANCHISE
Franchising is a long-term commercial concession agreement between companies, implying the transfer by one company of another of its right to use certain intellectual property objects within the specified territory.
D. Wafin, E. Hmelchenko
doaj +1 more source
THE AGREEMENT FOR THE CONCESSION OF PUBLIC ASSETS IN THE LIGHT OF THE ADMINISTRATIVE CODE [PDF]
As of 5 July 2019, the content of the essential normative act in the field of public administration in our country, namely the Administrative Code has been regulated the legal regime of the public and private property of the state and of the ...
Elena Emilia ȘTEFAN
doaj
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Actual Problems and Prospects for the Development of Public-Private Partnership in Russia
Russia is currently experiencing investment hunger, and the Russian economy is largely not to be invested. Public-private partnerships can serve as the main direction of the investment of the Russian economy.
Anatoly Yakovlevich Zaporozhan
doaj +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source

