Results 181 to 190 of about 281,352 (293)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Balancing different views in the contexts of voluntary assisted dying, safe access zones around reproductive health clinics, and the proposed Health Legislation Amendment (Conscientious Objection) Bill. [PDF]

Monash Bioeth Rev
Patten F.
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

An intuitionistic fuzzy automated negotiation model for personalized and efficient shared decision-making. [PDF]

Sci Rep
Lu P, Lu H, Wei Y, Dai B, Lin K, Wen S.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Strengthening Arboviral Epidemic Response Through Entomological Surveillance: Insights from Bobo-Dioulasso, Burkina Faso. [PDF]

Curr Issues Mol Biol
Laouali Z, Kagoné H, Kagoné T, Belem LRW, Konaté H, Ouari A, Zango A, Ouedraogo S, Yao RK, Diao WR, Manigart O, Ouédraogo AS, Diabaté A, Gnankiné O, Namountougou M.   +14 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Modeling the rise and demise of Classic Maya cities: Climate, conflict, and economies of scale. [PDF]

Proc Natl Acad Sci U S A
McCool WC, Codding BF, Degnan B, Ebert CE, Johnson ES, Vernon KB, Wilson KM, Beach T, Prufer KM, Kennett DJ.   +9 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

FSC-certified forest management benefits large mammals compared to non-FSC. [PDF]

Nature
Zwerts JA, Sterck EHM, Verweij PA, Maisels F, van der Waarde J, Geelen EAM, Tchoumba GB, Donfouet Zebaze HF, van Kuijk M.   +8 more
europepmc   +1 more source