FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Ethnic Accommodation and the Backlash From Dominant Groups. [PDF]
J Conflict ResolutJuon A.
europepmc +1 more source
Législation : Concessions déclarées d'utilité publique et pose des conducteurs dans des terrains privés. Questions des indemnités. Décisions diverses. [PDF]
, 1929 Paul Bougault
openalex +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Access in all areas? A round-up of developments in market access and health technology assessment: part 13. [PDF]
J Comp Eff ResRamagopalan SV, Pannelay AJ.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Exploring ideal scent detection dog characteristics for successful professional deployment as derived from face-to-face structured interviews with professional scent detection dog handlers. [PDF]
PLoS OneRoulaux PEM +3 more
europepmc +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Agent-based persuasion model with concessions dependent on emotion and time beliefs. [PDF]
PLoS OneWu J, Cao R, Zhang Y, Li Y.
europepmc +1 more source