Results 111 to 120 of about 1,204,981 (346)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Commentary: Association Between Antihypertensive Medication Use and Breast Cancer: A Systematic Review and Meta-Analysis

open access: yesFrontiers in Pharmacology, 2021
Natansh D. Modi   +5 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Endoscopic Retrograde Cholangiopancreatography followed by Laparoscopic Cholecystectomy versus Laparacosopic Cholecystectomy and Common Bile Duct Exploration in Concomitant Gallstone and Common Bile Duct Stone

open access: yesThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2016
Aim: Cholecystolithiasis is frequently accompanied with choledocholithiasis, with the incidence ranged from 8-20%. The current management of concomitant cholecystolithiasis and choledocholithiasis is varied, either Endoscopic Retrograde ...
Stefanus Satrio Ranty   +3 more
doaj  

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Concomitant Sounds and Colours [PDF]

open access: yesNature, 1870
THE investigation of the points of resemblance between two sciences, has its value and assists the development of both. Music gains by being thus raised from a mere sentimental recreation to the dignity of a science, but the science of colours may perhaps gain even more than music by the comparison, and this because the ear, in most persons, can ...
openaire   +2 more sources

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