Results 191 to 200 of about 1,610,336 (282)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Long-term Survival and Stroke after Cardiac Surgery with Concomitant Surgical Ablation for Atrial Fibrillation. [PDF]

Arrhythm Electrophysiol Rev
Sammut MA, Lee J, Cheong SC, Lim CJ, Singh M, Storey RF, Braidley PC, Briffa NP, Cartwright N, Chetty G, Forlani S, Greco R, Sadeque S, Hunter S.   +13 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Controversial efficacy of antithrombin followed by recombinant thrombomodulin administration in patients with sepsis-induced disseminated intravascular coagulation: an analysis of postmarketing surveillance data. [PDF]

Thromb J
Eguchi Y, Nagafuchi H, Ikeda T.
europepmc   +1 more source

CIRCADIAN RHYTHM OF STROKE VOLUME IN THE ACUTE PERIOD OF SEVERE CONCOMITANT TRAUMATIC BRAIN INJURY IN CHILDREN UNDER THE AGE OF THREE YEARS

H.N. Muhitdinova, Z.U. Babajanova, N.B.o. Bardibekov   +2 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Recognizing and addressing the challenges of concomitant cerebrocardiac infarction. [PDF]

World J Clin Cases
Tian X, Zhang N, Liu T.
europepmc   +1 more source

P957. Radiotherapy and concomitant chemo or hormonotherapy in early stage breast cancer: acute and late local toxicity

, 1997
Mariacarla Valli, L.F. Cazzaniga, Alberto Bossi, D. Cosentino, Luciano Scandolaro   +4 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Analysis of Risk Factors and Construction of a Prediction Model for Preoperative Concurrent Pathogenic Pyuria in Patients With Ureteral Calculi. [PDF]

Open Forum Infect Dis
Wu H, Zheng W, Bao H, Fu Y, Lin C, Liao Z, Ye Y, Wei M, Zhang Y.   +8 more
europepmc   +1 more source