Results 291 to 300 of about 1,204,981 (346)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Treatment modalities and patient reported outcomes in isolated and combined dorsal triquetrum chip fractures. [PDF]

Eur J Trauma Emerg Surg
Pasquinelli S, Tondelli T, Guenkel S.
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Etrasimod as a Monotherapy or With Concomitant Use of Corticosteroids and/or Aminosalicylates: Results From the ELEVATE UC Clinical Program. [PDF]

Inflamm Bowel Dis
Yarur AJ, Chiorean MV, Allegretti JR, Cross RK, Ha C, Goetsch M, McDonnell A, Dalam AB, Wu J, Blanco DA, Abbatemarco AM, Panés J.   +11 more
europepmc   +1 more source

Comparative Analysis of Labral Repair Characteristics in Patients Treated for Anterior versus Posterior Instability. [PDF]

Orthop J Sports Med
Hunter CDR, Da Silva AZ, McNamara NE, Wilde BM, Clinker CE, Chalmers PN, Ernat JJ.   +6 more
europepmc   +1 more source

Effectiveness and safety of concomitant use of direct oral anticoagulants and antiarrhythmic drugs: a systematic review of observational studies. [PDF]

Eur J Clin Pharmacol
Meinert FM, Dimakos J, Riemer TG, Douros A.   +3 more
europepmc   +1 more source

A predictive model for early detection of concomitant pulmonary embolism in patients with deep vein thrombosis immediately upon hospital admission. [PDF]

J Vasc Surg Venous Lymphat Disord
Gong M, Jiang R, Guo K, He X, Gu J.
europepmc   +1 more source

Streamlined concomitant pulse field ablation-based pulmonary vein isolation and left atrial appendage occlusion via a single venous access approach: a case report. [PDF]

Eur Heart J Case Rep
Heeger CH, Rolfes H, Böttcher L, Meincke F, Bergmann MW.   +4 more
europepmc   +1 more source