This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Process optimization and characterization of fatty acids and lipid concomitants in the aqueous extraction of camellia oil. [PDF]
Fan H +7 more
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Clozapine Therapy With or Without Antipsychotic Augmentation: A Retrospective Evaluation of Prescribing Practices in a Canadian Provincial Residential Treatment Centre for Concurrent Disorders: Traitement par la clozapine avec ou sans intensification à l'aide d'antipsychotiques : évaluation rétrospective des pratiques de prescription dans un centre de traitement résidentiel provincial canadien pour les troubles concomitants. [PDF]
Frankow L +3 more
europepmc +1 more source
On scalar concomitants of geometric objects and their transitive domains [PDF]
M. Kucharzewski, S. Węgrzynowski
openalex +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Les jeunes au Canada sont touchés par la crise des opioïdes et ont besoin de traitement. [PDF]
Charlebois S, Kelly S.
europepmc +1 more source
Novel fluidized-bed biofilm reactor for concomitant removal of microcystin-LR and organics
Pratik Kumar +6 more
openalex +2 more sources

