Results 141 to 150 of about 42,413 (300)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Proceedings of the Thoreau Museum of Natural History, Middlesex School, Concord, Massachusetts

v.1 pp.1-43 April 1910 - Mar ...
Thoreau Museum Of Natural History (Middlesex School (Concord, Mass.))
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Structured pelvic floor physiotherapy rehabilitation for low anterior resection syndrome in colorectal cancer: An Australian feasibility study. [PDF]

Support Care Cancer
Chan KYC, Suen M, Collett G, Coulson S, Warusavitarne J, Vardy JL.   +5 more
europepmc   +1 more source

Andrew Killian in Dyad 1929 by Wayne McGregor in rehearsal for the Concord season, the Australian Ballet, State Theatre, the Arts Centre, Melbourne, 2009, 1 [picture] /

, 2009
Title from acquisitions documentation, see file NLA12/324.; Part of the collection: The Australian Ballet in dress rehearsals for the 2007 Destiny season and 2009 Concord season, Melbourne.; Choreographed by Wayne McGregor.; Acquired in digital format ...
McFarlane, Jim, 1955-
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Tailoring survivorship care for older long-term survivors of breast and colorectal cancer. [PDF]

JNCI Cancer Spectr
Stevens SX, Malalasekera A, Tan SY, Vardy JL.   +3 more
europepmc   +1 more source

Dancers of the Australian Ballet in Dyad 1929 by Wayne McGregor in rehearsal for the Concord season, State Theatre, the Arts Centre, Melbourne, 2009, 14 [picture] /

, 2009
Title from acquisitions documentation, see file NLA12/324.; Part of the collection: The Australian Ballet in dress rehearsals for the 2007 Destiny season and 2009 Concord season, Melbourne.; Choreographed by Wayne McGregor.; Acquired in digital format ...
McFarlane, Jim, 1955-
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Feasibility and acceptability of "LiCPain" pilot randomised controlled trial of continuous subcutaneous infusion of lidocaine or placebo for people with neuropathic cancer pain: a qualitative study of patient and carer perceptions and experiences. [PDF]

BMC Palliat Care
Lee JT, Agar M, Phillips JL, Rao A, Huang E, Ritchie M, Fazekas B, Vandersman P, Aggarwal G, Mittal D, Sheehan C, Aggarwal R, Seah D, Kow M, George R, Chye R, Linton A, Noble B, Currow D, Ayoub C, Urban K, Sanderson C, Butcher BE, McLachlan A, Lovell MR.   +24 more
europepmc   +1 more source