Results 221 to 230 of about 42,413 (300)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spectrum of dominant Charcot-Marie-Tooth disease due to <i>SLC12A6</i> variants. [PDF]

J Neurol Neurosurg Psychiatry
Record CJ, Grider T, Rebelo AP, Laurini C, Skorupinska M, Danzi MC, Poh R, Tomaselli PJ, Frezatti RS, Dominik N, Grosz B, Ellis M, Kumar KR, Harms MB, Weihl CC, Marques Júnior W, Claeys KG, Blake JC, Holt JK, Weber A, Jacobson R, Dineen RT, Falzone YM, Previtali SC, Menezes MP, Vucic S, Laura M, Kennerson ML, Shy ME, Zuchner S, Reilly MM.   +30 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Contemporary Area-Level Mortgage Loan Denial Risk and Health-Related Quality of Life Among Cancer Survivors. [PDF]

Cancer Med
Brown JA, Ellington TD, Moubadder L, Bliss M, Kumar AD, Martin CL, Farnan L, Gerstel A, McCullough LE, Nichols HB.   +9 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Predicting clinical exacerbations using respiratory oscillometry during home telemonitoring of patients taking medium-/high-dose asthma treatment. [PDF]

ERJ Open Res
Thamrin C, Huvanandana J, Patel K, Farah CS, Reddel HK, Badal T, Cottee AM, Peters MJ, Dellacà RL, King GG, Gobbi A.   +10 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Resistant to Ablation, Responsive to Hydroquinidine: Precision Medicine Guides Recovery in MEPPC Syndrome Cardiomyopathy. [PDF]

J Arrhythm
Ciofani JL, Raju H, Anastasius M.
europepmc   +1 more source

Democratic caucus. Agreeable to a vote of the meeting the proceedings of which are subjoined, The Democrats of Concord, are requested to assemble at the Court House, on Saturday, the 5th day of February, inst. for the purpose of appointing Commi

Democratic party. Concord. N.H.
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Proceedings of the Thoreau Museum of Natural History, Middlesex School, Concord, Massachusetts

, 1910
Thoreau Museum Of Natural History (Middlesex School (Concord, Mass.))
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