Results 171 to 180 of about 313,878 (262)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Contralateral Knee Alignment Parameters Have Limited Influence on Coronal Alignment Progression Compared With Ipsilateral Parameters in Patients With Knee Osteoarthritis. [PDF]

Cartilage
Kang KS, Choi BS, Han HS, Chang CB, Chung K, Ro DH.   +5 more
europepmc   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Concordance of pathologic response assessment between local and central review in melanoma: a post hoc analysis of KEYMAKER-U02 substudy 02C. [PDF]

ESMO Open
Tetzlaff M, Taube JM, Long GV, Dummer R, Robert C, Menzies AM, Hill A, Gaudy-Marqueste C, Portnoy DC, Lebbe C, Krishnan R, Xu J, Fukunaga-Kalabis M, Krepler C, Scolyer RA.   +14 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Diagnostic Concordance and Interobserver Variability Between Tele-Dermatology (Store-and-Forward) and In-Person Evaluation for Inpatient Dermatology Consultations. [PDF]

Indian Dermatol Online J
Gupta P, Pandhi D, Grover C, Kumar R.
europepmc   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

State Trauma Center Designation Criteria and Expansion of For-Profit vs Nonprofit Trauma Centers.

JAMA Netw Open
Narayan S, Cho NY, Chattopadhyay K, Spain DA, Staudenmayer K, Choi J.   +5 more
europepmc   +1 more source

Retrospective comparison of ChatGPT-4 treatment recommendations with real-world physician management in newly diagnosed hypertension: a single-centre study. [PDF]

Front Cardiovasc Med
Gürses KM, Tezcan H, Tunçez A, Özen Y, Yalçın MU.   +4 more
europepmc   +1 more source