Results 201 to 210 of about 25,770 (266)

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

open access: yesSensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa   +5 more
wiley   +1 more source

Simulating strategic interactions with AI agents

open access: yesStrategic Management Journal, EarlyView.
Abstract Research Summary We explore how Large Language Models (LLMs) can serve as synthetic subjects to inform strategy research. We introduce a framework for designing and running simulated experiments with LLM‐powered agents. We argue that this approach is useful for rapid, low‐cost prototyping of human experiments and for generating novel ...
Matteo Tranchero   +3 more
wiley   +1 more source

Water Droplet Hammer: Piezoelectric Sensing of Ultrafast Mechanical Transients During Droplet Impact

open access: yesSmall, EarlyView.
Droplet impact on solid surfaces produces an ultrafast substrate‐coupled mechanical response that is resolved by PVDF piezoelectric sensing. An initial impulsive strain pulse is followed by interfacial oscillations before rebound. Weber‐number and timescale analyses reveal how droplet inertia, surface wettability, impact regime, and liquid viscosity ...
Ian Kim   +4 more
wiley   +1 more source

AI‐Revealed Transition From Density‐ to Connectivity‐Controlled Mechanics in Hierarchical Porous Materials

open access: yesSmall, EarlyView.
Using synchrotron‐based multiscale imaging, generative modeling algorithms, and computational mechanics models, our study reveals a scale‐dependent transition in bone mechanics. The results of the power‐scaling law illustrate a transition from density‐controlled stiffness at the trabecular scale to connectivity‐controlled, porosity‐sensitive mechanics ...
Milad Masrouri   +3 more
wiley   +1 more source

Innovative 3D‐bioprinted microfibers in calcium phosphate cement platform with Nell‐1 to activate nerve‐bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration

open access: yesSmart Molecules, EarlyView.
A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu   +11 more
wiley   +1 more source

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