Results 121 to 130 of about 96,976 (366)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

L’ANACHRONISME DE LA LÉGISLATION PUBLICITAIRE EN RÉPUBLIQUE DÉMOCRATIQUE DU CONGO [PDF]

Cahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable, 2022
De nos jours, la publicité est omniprésente. Elle est devenue le trait caractéristique de la société de consommation et élément indispensable au fonctionnement de l’économie.
Dr Casimir ILUNGA KASAMBAY
doaj  

The concurrence of musculoskeletal pain and associated work-related factors: a cross sectional study

BMC Public Health, 2016
BackgroundSeveral recent studies have described the presence of musculoskeletal complaints, presenting evidence that multisite musculoskeletal pain (MP) is more often present than single-site musculoskeletal pain.
R. de Cássia Pereira Fernandes, Silvana Maria da Silva Pataro, Roberta Brasileiro de Carvalho, A. Burdorf   +3 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Strategies as Concurrent Processes

Electronic Notes in Theoretical Computer Science, 2014
AbstractConcurrent strategies are shown to support operations yielding an economic yet rich higher-order concurrent process language, which shares features both with process calculi and nondeterministic dataflow. Its operational semantics and ‘may and must’ equivalence require that we take internal (neutral) moves seriously, leading to the introduction
Castellan, Simon, Hayman, Jonathan, Lasson, Marc, Winskel, Glynn   +3 more
openaire   +5 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Truly Concurrent Bisimilarities are Game Equivalent [PDF]

arXiv, 2019
We design games for truly concurrent bisimilarities, including strongly truly concurrent bisimilarities and branching truly concurrent bisimilarities, such as pomset bisimilarities, step bisimilarities, history-preserving bisimilarities and hereditary history-preserving bisimilarities.
arxiv  

Genuine multipartite entanglement detection and lower bound of multipartite concurrence [PDF]

, 2015
The problems of genuine multipartite entanglement detection and classification are challenging. We show that a multipartite quantum state is genuine multipartite entangled if the multipartite concurrence is larger than certain quantities given by the ...
Ming Li, S. Fei, X. Li-Jost, H. Fan
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source