Results 81 to 90 of about 15,889,209 (373)

Staring into the Abyss: An Evaluation of Concurrency Control with One Thousand Cores

Proceedings of the VLDB Endowment, 2014
Computer architectures are moving towards an era dominated by many-core machines with dozens or even hundreds of cores on a single chip. This unprecedented level of on-chip parallelism introduces a new dimension to scalability that current database ...
Xiangyao Yu, George B. P. Bezerra, Andrew Pavlo, S. Devadas, M. Stonebraker   +4 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Distributed Concurrency Control [PDF]

, 2011
As we discussed in Chapter 10, concurrency control deals with the isolation and consistency properties of transactions. The distributed concurrency control mechanism of a distributed DBMS ensures that the consistency of the database, as defined in Section 10.2.2, is maintained in a multiuser distributed environment.
M. Tamer Özsu, Patrick Valduriez
openaire   +2 more sources

A Deep Reinforcement Learning-Based Concurrency Control of Federated Digital Twin for Software-Defined Manufacturing Systems

Applied Sciences
Modern manufacturing demands real-time, scalable coordination that legacy manufacturing management systems cannot provide. Digital transformation encompasses the entire manufacturing infrastructure, which can be represented by digital twins for ...
Rubab Anwar, Jin-Woo Kwon, Won-Tae Kim
doaj   +1 more source

Cache affinity optimization techniques for scaling software transactional memory systems on multi-CMP architectures [PDF]

, 2015
Software transactional memory (STM) enhances both ease-of-use and concurrency, and is considered one of the next-generation paradigms for parallel programming. Application programs may see hotspots where data conflicts are intensive and seriously degrade
Chan, K, Lam, KT, Wang, CL
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A thread-tag based semantics for sequence diagrams [PDF]

, 2007
The sequence diagram is one of the most popular behaviour modelling languages which offers an intuitive and visual way of describing expected behaviour of object-oriented software.
Counsell, S, Dan, H, Hierons, RM
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design Principles for Scaling Multi-core OLTP Under High Contention

, 2016
Although significant recent progress has been made in improving the multi-core scalability of high throughput transactional database systems, modern systems still fail to achieve scalable throughput for workloads involving frequent access to highly ...
Abadi, Daniel J., Faleiro, Jose M., Ren, Kun   +2 more
core   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source