Results 141 to 150 of about 2,069 (285)

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Experimental study on the mechanism of ice layer formation in fractured rock masses in cold regions. [PDF]

Sci Rep, 2022
Wang L, Dong Z, Li N, Wang W, Tian Y, Xu S.   +5 more
europepmc   +1 more source

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source

Research in the development of an improved multiplier phototube Final report [PDF]

Cascade aperture design, gas pressure effects, gain calibration, and photon counting efficiency of multiplier ...
Barr, F. H., Eberhardt, E. H.
core   +2 more sources

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source

MetaMask for thermal-humidity regulation in cold-environment facial protection. [PDF]

Natl Sci Rev
Wang Q, Yang Y, Liang Q, Yu J.
europepmc   +1 more source

Synergistic Hydrogen‐Bonding and Covalent Crosslinking in Polybenzimidazole Membranes for Wide‐Temperature Anhydrous Fuel Cells

Advanced Science, EarlyView.
A dual‐network architecture combining a thermally reinforced hydrogen‐bonding matrix with an amine‐anhydride covalent framework was constructed in Tröger's Base (TB)‐functionalized polybenzimidazoles. This design yielded the TBAm‐PBI‐TB membrane with high acid uptake (469.5%), anhydrous conductivity (264.7 mS cm−1), and robust stability.
Junming Dai, Jianming Zhong, Jinpeng Luo, Yuxing Song, Fan Hu, Young Moo Lee, Yongbing Zhuang   +6 more
wiley   +1 more source

Electrostatic Defrosting. [PDF]

Small Methods
Lolla VY, Zhang H, Socha BZ, Qiao R, Boreyko JB.   +4 more
europepmc   +1 more source

Transparent Photothermal Slippery Surface Based on Monolayer Self‐Assembled MXene Film for Anti‐Fogging and De‐Icing

Advanced Science, EarlyView.
The ultrathin (2.5 nm) MXene film self‐assembled at liquid interfaces breaks the trade‐off between transparency (82.5 %) and photothermal conversion effect (DT∼25.1°C ± 2.9 °C) under 100 mW cm−2. After encapsulated by a slippery surface with low adhesion, this transparent film can be applied in smart windows, eyewear, and optical sensors to autonomous ...
Xiao Han, Yiming Xie, Mingjia Sun, Di Zhao, Kesong Liu, Liping Heng, Lei Jiang   +6 more
wiley   +1 more source

Editorial for the Special Issue on Heat and Mass Transfer in Microchannels. [PDF]

Micromachines (Basel)
Xiao X, Zhang X, Zhang L.
europepmc   +1 more source