Results 101 to 110 of about 6,287 (213)

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

open access: yesAdvanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato   +5 more
wiley   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao   +12 more
wiley   +1 more source

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

open access: yesAdvanced Science, EarlyView.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen   +23 more
wiley   +1 more source

Ultra‐Robust Conductive Hydrogels Enabled by a Gradient Bond‐Breaking Pseudo‐Drying Strategy

open access: yesAdvanced Science, EarlyView.
A bioinspired PVA‐ANFs hydrogel, engineered via novel gradient bond‐breaking, achieves unprecedented mechanical performance: ultrahigh strength (≈18 MPa), modulus (≈12 MPa), toughness (≈74 MJ/m3), and record fracture energy (≈269 kJ m−2). It exhibits cryogenic flexibility (−70°C), high ionic conductivity (936.3 mS m−1), and biocompatibility.
Dongchao Ji   +11 more
wiley   +1 more source

Melting of nonreciprocal solids: How dislocations propel and fission in flowing crystals. [PDF]

open access: yesProc Natl Acad Sci U S A
Guillet S   +5 more
europepmc   +1 more source

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