Results 111 to 120 of about 6,287 (213)

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid‐Liquid Phase Separation

Advanced Science, EarlyView.
Muscle‐specific RPS27L knock‐in mice exhibit increased body weight, muscle mass, and enhanced muscle regenerative capacity. RPS27L drives myogenesis by promoting myoblast proliferation, while inhibiting myogenic differentiation. Mechanistically, RPS27L targets IGF1 protein by liquid‐liquid phase separation through its N‐terminal intrinsically ...
Xiaoqin Liu, Yilong Yao, Junyu Yan, Mu Zeng, Xinhao Fan, Yijie Tang, Jiju Li, Yanwen Liu, Shanying Yan, Wei Wang, Lijuan Chen, Ruipu Chen, Yuxin Huang, Honor Calnan, Heng Wang, Graham Gardner, Yalan Yang, Zhonglin Tang   +17 more
wiley   +1 more source

Mean Field Approaches to Lattice Gauge Theories: A Review. [PDF]

Entropy (Basel)
Fontana P, Trombettoni A.
europepmc   +1 more source

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Evaluating 3D Hand Scanning Accuracy Across Trained and Untrained Students. [PDF]

Bioengineering (Basel)
Glazer C, Oravitan M, Pantea C, Almajan-Guta B, Jurjiu NA, Marghitas MP, Avram C, Stanila AM.   +7 more
europepmc   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Fractional-statistics-induced entanglement from Andreev-like tunneling. [PDF]

Nat Commun
Zhang G, Glidic P, Pierre F, Gornyi I, Gefen Y.   +4 more
europepmc   +1 more source

Fundamentals of Charged Particle Transport in Gases and Condensed Matter

, 2017
R. Robson, R. White, M. Hildebrandt
semanticscholar   +1 more source

Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts

Advanced Science, EarlyView.
Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Stephanie E. Schneider, Adrienne K. Scott, Katie M. Gallagher, Emily Y. Miller, Soham Ghosh, Corey P. Neu   +5 more
wiley   +1 more source

Random Transitions of a Binary Star in the Canonical Ensemble. [PDF]

Entropy (Basel)
Chavanis PH.
europepmc   +1 more source

Out of the Crystalline Comfort Zone: Sampling the Initial Oxide Formation At Cu(111)

Advanced Science, EarlyView.
By combining replica exchange molecular dynamics with fast and efficient machine‐learned interatomic potentials, this computational study predicts the complex surface reconstructions accompanying the early Cu(111) surface oxidation. The unprecedentedly exhaustive sampling results in a high‐quality surface phase diagram that not only recovers known ...
Felix Riccius, Nicolas Bergmann, Hendrik H. Heenen, Karsten Reuter   +3 more
wiley   +1 more source