Results 121 to 130 of about 5,571 (214)

A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy

Advanced Science, EarlyView.
The work developed a closed‐loop hybrid discovery system to rationally design and predict high‐performance Type I PSs for hypoxic tumor therapy. 664 Potential candidates are identified from a dataset through a support vector machine (SVM) classification model, and two candidates are experimentally verified as Type I PSs, which highlighted the potential
Xia Ling, Yixin Zhu, Min Li, Zongliang Xie, Lei Cao, Wentao Song, Dandan Wang, Duo Mao, Xiaonan Wang, Bin Liu   +9 more
wiley   +1 more source

Dynamical spin susceptibility and magnetic ordering in a square-octagon lattice in the Hubbard model. [PDF]

Sci Rep
Abdi M, Astinchap B, Norian E.
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Measurement of the dynamic charge susceptibility near the charge density wave transition in ErTe₃. [PDF]

Proc Natl Acad Sci U S A
Chaudhuri D, Jiang Q, Guo X, Chen J, Kengle CS, Hoveyda-Marashi F, Bernal-Choban C, de Vries N, Chiang TC, Fradkin E, Fisher IR, Abbamonte P.   +11 more
europepmc   +1 more source

Atomically Resolved Electron Reflectivity at a Metal/Semiconductor Interface

Advanced Science, EarlyView.
An atomically flat interface is achieved in the incoherent Al/Ge heterostructure using molecular beam epitaxy (MBE). Scanning tunneling microscopy (STM) reveals a laterally periodic modulation of electron reflectivity with atomic resolution at the commensurate Al/Ge interfacial lattice, originating from the local electronic states.
Ding‐Ming Huang, Jian‐Huan Wang, Jie‐Yin Zhang, Yuan Yao, Hongqi Xu, Jian‐Jun Zhang   +5 more
wiley   +1 more source

Many-body interference in kagome crystals. [PDF]

Nature
Guo C, Wang K, Zhang L, Putzke C, Chen D, van Delft MR, Wiedmann S, Balakirev FF, McDonald RD, Gutierrez-Amigo M, Alkorta M, Errea I, Vergniory MG, Oka T, Moessner R, Fischer MH, Neupert T, Felser C, Moll PJW.   +18 more
europepmc   +1 more source

Magnesium Structure‐Function Integration Platform for Spatiotemporal Multi‐Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
The schematic illustration of the MHSCG platform for spatiotemporal responsive GRb1 release to induce androgen deprivation therapy (ADT) and immunogenic cell death (ICD) multimodal therapy in prostate cancer. Abstract Metal‐based immunotherapy represents a promising strategy for enhancing antitumor efficacy; however, its clinical application is limited
Rui Zan, Qianping Mao, Keyi Wang, Guodong Zou, Shi Yang, Hua Qiu, Xiang Fang, Guiqing Wang, Xinyi Zhou, Jiexia Wen, Shuai Jiang, Ran Huang, Qiuming Peng, Tao Suo   +13 more
wiley   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

Advanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu   +18 more
wiley   +1 more source

Berry curvature driven transverse thermoelectric generation in topological magnets. [PDF]

Sci Technol Adv Mater
Sakai A, Nakatsuji S.
europepmc   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source