T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Precise structure and polarization determination of Hf<sub>0.5</sub>Zr<sub>0.5</sub>O<sub>2</sub> with electron ptychography. [PDF]
Gao X +12 more
europepmc +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Large Room Temperature Anomalous Nernst Effect Coupled with Topological Nernst Effect from Incommensurate Spin Structure in a Kagome Antiferromagnet. [PDF]
Ma J +8 more
europepmc +1 more source
Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
First-Principles Study of Biaxial Strain Effects on Schottky Barrier Modulation in Graphene/ZnSe Heterostructures. [PDF]
Pang G, Wen X, Zhang L, Huang Y.
europepmc +1 more source
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci +13 more
wiley +1 more source
Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar +9 more
wiley +1 more source
Harmonic non-Hermitian skin effect. [PDF]
Zhang Q, Xiong L, Tong S, Qiu C.
europepmc +1 more source

