Results 211 to 220 of about 1,220,737 (270)

A surrogate endpoint-based provisional approval causal roadmap, illustrated by vaccine development. [PDF]

Biostatistics
Gilbert PB, Peng J, Han L, Lange T, Lu Y, Nie L, Shih MC, Waddy SP, Wiley K, Yann M, Zafari Z, Ghosh D, Follmann D, Juraska M, Díaz I.   +14 more
europepmc   +1 more source

Nonparametric maximum likelihood estimation of the survival function using current lifetime data

Canadian Journal of Statistics, EarlyView.
Abstract An issue when estimating the failure time survival function is how to set up a prevalent cohort study infrastructure to follow subjects after enrollment. This problem can be circumvented through the well‐known Grenander density estimator using current lifetime observations only.
James H. McVittie, Masoud Asgharian
wiley   +1 more source

AI-assisted reliability-based design framework for tunnel concrete linings in weak rocks. [PDF]

Sci Rep
Khani J, Nejati HR, Goshtasbi K, Rostamabadi S, Mahmoodzadeh A.   +4 more
europepmc   +1 more source

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Job Replacement Anxiety and Approach-Avoidance Job Crafting: The Roles of Regulatory Focus and AI Literacy. [PDF]

Behav Sci (Basel)
Fan C, Wang H.
europepmc   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Coconut: covariate-assisted composite null hypothesis testing with applications to replicability analysis of high-throughput experimental data. [PDF]

BMC Bioinformatics
Li Y, Li Y, Ma H, Yue Z, Zhang X.
europepmc   +1 more source

A Meta‐Analytic Review of Board Characteristics and Carbon Emission Disclosure: The Moderating Effect of Contextual Factors

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The relationship between board governance and corporate carbon emission disclosure remains persistently inconsistent across the empirical literature, despite decades of accumulated evidence. Drawing on agency, stakeholder, legitimacy, institutional, and upper echelons perspectives within a single analytical framework, we conduct a three‐level ...
Mohamed Hegazy, Diego Prior, Mahmoud Zarea   +2 more
wiley   +1 more source

Using Propensity Score Weighting With Clustered Data When the Treatment Is Applied at the Level of the Cluster and Outcomes Are Assessed at the Level of the Individual: The Observational Analog of Cluster Randomization Trials. [PDF]

Stat Med
Austin PC.
europepmc   +1 more source