Results 61 to 70 of about 330,463 (281)

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

The Convergence of Food Expenditures in the European Union Countries – a Spatio‑Temporal Approach

Acta Universitatis Lodziensis. Folia Oeconomica, 2019
The paper presents the analysis of the convergence of household final consumption expenditures on food in the European Union countries in the period of 1999–2015, considering spatial and spatio‑temporal tendencies and dependencies.
Mateusz Jankiewicz
doaj   +1 more source

A modification of the convergence conditions for Picard's iteration [PDF]

Computational & Applied Mathematics, 2004
To solve by successive approximation nonlinear equations of the form F(x)=0, where F:Ω⊆X→X, is an operator defined on an open convex domain of a Banach space X with values in X, one uses a fixed point theorem based method which requires the operator G(x)=x−F(x) to be a contraction. This has a very limited scope of applicability.
Ezquerro, J. A., Hernández, M. A.
openaire   +5 more sources

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Weaker convergence conditions for the secant method [PDF]

Applications of Mathematics, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Argyros, Ioannis K., Hilout, Saïd
openaire   +2 more sources

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Data‐Driven Fatigue Prediction of Superalloys: A Novel Strategy Integrating Transfer Learning and Partial Label Learning for Addressing Ambiguous Data

Advanced Science, EarlyView.
A novel machine learning strategy tackles ambiguous compositional data to predict superalloy fatigue. By integrating partial label with transfer learning and enriching features through thermodynamic calculations, this approach achieves superior accuracy and interpretability.
Haopeng Lv, Jiawei Yin, Dayong Wu, Ziyuan Rao, Chao Su, Jie Kang, Qian Wang, Haikun Ma, Huicong Dong, Yandong Wang, Ru Su   +10 more
wiley   +1 more source

The Analysis of Income per Capita Convergence on ASEAN Plus Three (APT) Countries

Sriwijaya International Journal of Dynamic Economics and Business, 2017
The main objective of this study is to test the convergence of income per capita in APT countries through three models: absolute convergence, conditional convergence and sigma convergence.
Any Fatiwetunusa, Syamsurijal Syamsurijal, Sa'adah Yuliana   +2 more
doaj   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source