Results 161 to 170 of about 2,723 (234)

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu   +2 more
wiley   +1 more source

I feel like an outcast!: qualitative exploration on barriers to seek care among women with obstetric fistula in Tigray, Northern Ethiopia. [PDF]

open access: yesReprod Health
Weldu LM   +12 more
europepmc   +1 more source

Where Have I Seen You Before? Networks, Trust and Reciprocity as a Source of Collaboration in the Public Service

open access: yesPublic Administration and Development, EarlyView.
ABSTRACT Although some studies focus on how bureaucrats' interactions with one another affect performance, they rarely focus on why these public servants collaborate. Bureaucrats' collaboration matters because it can significantly contribute to achieving policy goals.
Nathalie Mendez
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

Reduced social support perpetuates disadvantage across the lifespan for Australian women. [PDF]

open access: yesBMC Womens Health
Robertson AM   +7 more
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said   +10 more
wiley   +1 more source

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