Results 161 to 170 of about 2,971 (269)

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Droit du divorce : conditions - effets - procédure

, 2020
Leuba, Audrey, Meier, Philippe, Papaux van Delden, Marie-Laure   +2 more
openaire   +1 more source

The Jurisprudential Regulations Extracted from Bada’i’ al-Sana’i’ Book, Divorce Chapter

الأهداف: تهدف الدراسة إلى إبراز عناية الإمام الكاساني بالضوابط الفقهية في كتابه بدائع الصنائع، بالإضافة إلى إثراء علم الضوابط الفقهية بذكر صيغ جديدة مستخلصة من باب الطلاق من كتاب بدائع الصنائع، مع بيان المقصود بهذه الضوابط، وإيراد الأدلة التي تستند إليها،
Mousa, Moayad Hamdan Mahmoud
core  

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Patterns of sex-specific and age-specific risk indicators of suicide: a population-nested case-control study. [PDF]

BMJ Ment Health
Johansson F, Gunnarsson L, Grossmann L, Mataix-Cols D, Fernández de la Cruz L, Fazel S, Gardner RM, Dalman C, Wallert J, Rück C.   +9 more
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Causal inference in multi-cohort studies using the target trial framework to identify and minimize sources of bias. [PDF]

Am J Epidemiol
Downes M, O'Connor M, Olsson CA, Burgner D, Goldfeld S, Spry EA, Patton G, Moreno-Betancur M.   +7 more
europepmc   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Parents' divorce and early child development: a population-based study in China. [PDF]

BMJ Paediatr Open
Kang L, Yin R, Deng Y, Zhang Y, Zhao J, Song Y, Jiang F, Lu C.   +7 more
europepmc   +1 more source

Machine learning‐driven advances in carbon‐based quantum dots: Opportunities accompanied by challenges

Responsive Materials, EarlyView.
Machine learning provides a unifying framework to connect structure, fluorescence properties, and applications of carbon‐based quantum dots. This review highlights how data‐driven strategies enable fluorescence regulation, reveal underlying mechanisms, and accelerate the rational design of functional carbon dots.
Liangfeng Chen, Siwei Yang, Xiangqian Cui, Ziheng Liu, Hang Wang, Yongqiang Li, Peng He, Miao Wang, Guqiao Ding   +8 more
wiley   +1 more source