Results 101 to 110 of about 918 (167)

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1744-1759, June 2026.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet   +17 more
wiley   +1 more source

A goodness‐of‐fit test for regression models with discrete outcomes

open access: yesCanadian Journal of Statistics, Volume 54, Issue 2, June 2026.
Abstract Regression models are often used to analyze discrete outcomes, but classical goodness‐of‐fit tests such as those based on the deviance or Pearson's statistic can be misleading or have little power in this context. To address this issue, we propose a new test, inspired by the work of Czado et al.
Lu Yang   +2 more
wiley   +1 more source

Masting Breakdown in European Beech Reduces Fitness Benefits of Masting, Partly Explained by Climate Change

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
Synchrony and inter‐annual variation in annual seed production of European beech (Fagus sylvatica) strongly declined over time, resulting in a masting breakdown. As a consequence, predation rsik for seeds strongly increased, while pollination success declined.
Cherine C. Jantzen   +4 more
wiley   +1 more source

Framing Effects on Public Support and Behavioral Responses to Sustainable Forest Management in South Korea

open access: yesEnvironmental Policy and Governance, Volume 36, Issue 3, Page 444-459, June 2026.
ABSTRACT Despite South Korea's extensive forest coverage, which accounts for approximately 63% of its total land area, the country imports over 83% of its timber needs and has shown a gradual decline in forest carbon sequestration capacity. The Circular Forest Management Policy (CFMP) addresses these challenges through systematic forest resource ...
Seoryeon Son   +4 more
wiley   +1 more source

Strategic Delay and Bargaining Over Public Insurance Coverage for Drugs in Australia

open access: yesHealth Economics, Volume 35, Issue 6, Page 1005-1018, June 2026.
ABSTRACT Public funding for pharmaceuticals often follows repeated negotiation between manufacturers and a public agency, yet little empirical work examines how the timing of agreement reflects the economic structure of these interactions. Using a duration model of negotiations in Australia from 2005 to 2018, we assess whether observed patterns of ...
Jing Jing Li, Anthony Harris
wiley   +1 more source

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