Results 61 to 70 of about 950 (184)

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

open access: yesEpilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley   +11 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira   +5 more
wiley   +1 more source

Graph Neural Network‐Based Prediction of Building Energy Consumption

open access: yesEnergy Science &Engineering, EarlyView.
A graph neural network that encodes a multi‐zone building as a graph accurately predicts hourly cooling and heating loads across three distinct climates, outperforming Random Forest and XGBoost baselines and serving as a fast surrogate to EnergyPlus simulations for scalable building energy management.
Ali Maboudi Reveshti   +4 more
wiley   +1 more source

DSGE Model Forecasting: Rational Expectations Versus Adaptive Learning

open access: yesJournal of Forecasting, EarlyView.
ABSTRACT This paper compares within‐sample and out‐of‐sample fit of a DSGE model with rational expectations to a model with adaptive learning. The Galí, Smets, and Wouters model is the chosen laboratory using quarterly real‐time euro area data vintages, covering 2001Q1–2019Q4.
Anders Warne
wiley   +1 more source

Assessing the Estimands and Estimates of Hospitalization Rates in Health Economics and Clinical Medicine

open access: yesHealth Economics, EarlyView.
ABSTRACT Even though data on hospital admissions are widely used in health research, hospitalization‐related estimands measured using these data are not always clearly conceptualized. Consequently, estimators of these quantities can have unclear rationales and undesirable properties.
Aditya Jain   +7 more
wiley   +1 more source

Treatment With the Shaker Head‐Lift Exercise in Head and Neck Cancer Patients With Radiation‐Induced Dysphagia: 12‐Month Results on Swallowing Function From a Randomized, Controlled Trial

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Dysphagia is a common side‐effect after radiotherapy in head and neck cancer patients. This randomized study aimed to evaluate the effect of the shaker head‐lift exercise (HLE) after 12 months with flexible endoscopic evaluation of swallowing (FEES). Methods Patients were randomly assigned to the intervention (n = 30) or the control
Signe Rödseth Smith   +3 more
wiley   +1 more source

Who Knows Best What the Next Year Will Hold for You? The Validity of Direct and Personality‐based Predictions of Future Life Experiences Across Different Perceivers

open access: yesEuropean Journal of Personality, EarlyView., 2020
Abstract This study explored the validity of person judgements by targets and their acquaintances (‘informants’) in longitudinally predicting a broad range of psychologically meaningful life experiences. Judgements were gathered from four sources (targets, N = 189; and three types of informants, N = 1352), and their relative predictive validity was ...
Nele M. Wessels   +3 more
wiley   +1 more source

Embracing Complexity in HRM Research: A Call for System and Process Perspectives

open access: yesHuman Resource Management, EarlyView.
ABSTRACT Human resource management (HRM) is inherently complex. It involves systems of principles, practices, and activities operating at individual, group, organizational, and macro levels, which are interlinked through complex processes. Yet, empirical research has not kept pace with this conceptual richness.
Rebecca Hewett, Madleen Meier‐Barthold
wiley   +1 more source

Holding out on restructuring negotiations: A legal analysis over Finnish and Swedish legislation

open access: yesInternational Insolvency Review, EarlyView.
Abstract This article examines how Finnish and Swedish restructuring laws create opportunities for creditors to hold out on restructuring negotiations. Using Anthony Casey's new bargaining theory and the traditional creditors' bargain model as analytical frames, the study argues that holdouts arise when ex ante rights – particularly security interests,
Anssi Kärki
wiley   +1 more source

Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort

open access: yesInternational Journal of Cancer, EarlyView.
The immune system has been implicated as a major driver in pancreatic cancer etiology. Previous cohort studies have found associations between pancreatic cancer and single immune system‐derived markers, but omics‐based evidence remains scarce. In this prospective case–control study, the authors investigated 92 proteins involved in immune reactions and ...
Verena A. Katzke   +28 more
wiley   +1 more source

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