Results 81 to 90 of about 1,044,082 (362)

Generation of SARS-CoV-2 dual-target candidate inhibitors through 3D equivariant conditional generative neural networks

Journal of Pharmaceutical Analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are influenced by random and uncontrollable factors, and the risk of the next widespread epidemic remains.
Zhong-Xing Zhou, Hong-Xing Zhang, Qingchuan Zheng   +2 more
doaj   +1 more source

Generalized probability model for calculation of interference to the Deep Space Network due to circularly Earth-orbiting satellites [PDF]

, 1992
The probability of exceeding interference power levels and the duration of interference at the Deep Space Network (DSN) antenna is calculated parametrically when the state vector of an Earth-orbiting satellite over the DSN station view area is not known.
Ruggier, C. J.
core   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Information In The Non-Stationary Case [PDF]

, 2008
Information estimates such as the ``direct method'' of Strong et al. (1998) sidestep the difficult problem of estimating the joint distribution of response and stimulus by instead estimating the difference between the marginal and conditional entropies ...
Kass, Robert E., Vu, Vincent Q., Yu, Bin
core   +3 more sources

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

A Conditional-Probability-Distribution Model for Bandwidth Estimation with Application in Live Video Streaming [PDF]

, 2022
Weijia Zheng
openalex   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Synchronous-Asynchronous Encounter Probability Analysis of High-Low Runoff for Jinsha River, China, using Copulas*

MATEC Web of Conferences, 2018
Synchronous-asynchronous encounter probability analysis of high-low runoff, which requires a description of the probabilistic properties of hydrological variables, is important in regional water resources management.
Jing CHEN, Shixiang GU, Tianli ZHANG
doaj   +1 more source

Risk Analysis through the Half-Normal Distribution

Mathematics, 2020
We study the applicability of the half-normal distribution to the probability–severity risk analysis traditionally performed through risk matrices and continuous probability–consequence diagrams (CPCDs).
Maria-Teresa Bosch-Badia, Joan Montllor-Serrats, Maria-Antonia Tarrazon-Rodon   +2 more
doaj   +1 more source

Conditional Transformation Models

, 2012
The ultimate goal of regression analysis is to obtain information about the conditional distribution of a response given a set of explanatory variables.
Bühlmann, Bühlmann, Bühlmann, Bühlmann, Chen, Chen, Cheng, Cheng, Currie, Dette, Doksum, Eilers, Fenske, Friedman, Gilchrist, Gneiting, Gneiting, Gneiting, Hall, Hall, Hayfield, He, Hofner, Hothorn, Koenker, Koenker, Koenker, Kriegler, Li, Lu, Lu, Mayr, Ridgeway, Rigby, Schemper, Schild, Schmid, Schnabel, Sexton, Shen, Tutz, Tutz, van de Geer, Wu, Zeng, Zheng   +45 more
core   +1 more source