Results 91 to 100 of about 141,957 (262)

Machine learning-based price forecasting and risk management in renewable energy markets

Sustainable Energy Research
The rising share of renewable energy has amplified electricity price volatility, underscoring the need for accurate forecasting and robust risk management.
Kuochun Lin, Peichun Feng
doaj   +1 more source

Conditional Value-at-Risk for General Loss Distributions

SSRN Electronic Journal, 2001
Fundamental properties of conditional value-at-risk, as a measure of risk with significant advantages over value-at-risk, are derived for loss distributions in finance that can involve discreetness. Such distributions are of particular importance in applications because of the prevalence of models based on scenarios and finite sampling.
Department of Mathematics, University of Washington, P.O. Box 354350, Seattle, WA 98195-4350, USA ( host institution ), Rockafellar, R.Tyrrell ( author ), Uryasev, Stanislav ( author )   +2 more
openaire   +2 more sources

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Examining the Relationship between Diversification of Banking Resources and Expenses and Systemic Risk [PDF]

راهبرد مدیریت مالی
The purpose of this article was to investigate the relationship between the diversification of banking resources and expenses with systemic risk in the country's banking system.
Yazdan Gudarzi Farahani, Zoleikha Morsali Arzanagh, Mohsen Mehrara   +2 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

On a Multivariate Extension for Copula-Based Conditional Value at Risk

Journal of Statistical Theory and Applications (JSTA)
Copula-based Conditional Value at Risk ( $$\textrm{CCVaR}$$ ) is a real-valued tail risk measure for multivariate random vectors defined through conditioning on a copula level set.
Andres Mauricio Molina Barreto
doaj   +1 more source

Hedging Risks in the Loss-Averse Newsvendor Problem with Backlogging

Mathematics, 2019
This paper studies the optimal order decisions for the loss-averse newsvendor problem with backordering and contributes to the risk hedging issue in the newsvendor model.
Xiaoqing Liu, Felix T. S. Chan, Xinsheng Xu   +2 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

APPLICATION OF THE RANDOM FOREST ALGORITHM FOR ESTIMATING CONDITIONAL VALUE AT RISK (CVAR) ON THE STOCK PORTFOLIO OF INSURANCE COMPANIES IN INDONESIA

Barekeng
This study aims to estimate Conditional Value at Risk (CVaR) for insurance company stock portfolios using a machine learning approach to improve the accuracy of financial risk measurement under extreme market conditions.
Purwanto Purwanto, Agna Olivia
doaj   +1 more source