Results 231 to 240 of about 46,274,052 (301)

Climate Change is Rewriting the Hydroclimatic Operating Envelope of Mines

Advanced Science, EarlyView.
Climate change is shown to shift the hydroclimatic operating envelope of mines: 16.2% of represented mine locations have already changed Köppen subtype, rising to 42.5% by late century under SSP5‐8.5. Divergent water trajectories are filtered through geology, infrastructure and lifecycle stage, indicating that adaptation requires monitored, scenario ...
Haoxuan Yu, Izni Zahidi, Chow Ming Fai, Jilong Pan   +3 more
wiley   +1 more source

Identification of recurrence risk factors and development of personalized follow-up strategies for esophageal squamous cell carcinoma patients after neoadjuvant therapy and surgery: a retrospective cohort study. [PDF]

J Thorac Dis
Cai Y, Wei N, Cai X, Ding J, Teng C, Chen L.   +5 more
europepmc   +1 more source

Toward Rational Design of Aqueous Battery Membranes Beyond the Selectivity‐Conductivity Trade‐Off

Advanced Science, EarlyView.
This review examines sulfonated membranes for redox flow batteries. It focuses on proton transport mechanism, membrane design, performance limits, optimization strategies, and the pathway from molecular design to membrane manufacturing. ABSTRACT Electrochemical energy‐storage systems increasingly require membranes that can simultaneously deliver fast ...
Jinkang Liu, Mingbo Xie, Zhenghao Wang, Huacun Li, Jun Xie, Pan Liu, Qingwei Wang, Xu Yan, Meiqing Shi, Liyuan Chai, Yue Luo, Zining Tang, Rui Tan, Liyuan Zhang   +13 more
wiley   +1 more source

Critical Appraisal of Causality Observational Studies: A Case-Study of the Effect of Tattoo on Malignant Lymphoma. [PDF]

Int J Prev Med
Mansournia MA, Nazemipour M.
europepmc   +1 more source

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

Advanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo, Cheng‐Chen Hou, Wei Wang, Ya‐Xuan Zhu, Ling Li, Li‐Juan Liu, Chuan‐Jian Lu, Peng‐Fei Tu, Yang Liu, Rui‐Zhi Zhao, Ke‐Wu Zeng   +10 more
wiley   +1 more source

Immune Profile and Risk of COVID-19-Associated Pulmonary Aspergillosis (CAPA): A Multicenter Retrospective Study with Matching Cohorts. [PDF]

J Fungi (Basel)
Mascle O, Dupuis C, Lafarge A, Moniot M, Evrard B, Poirier P, Joseph A, Azoulay E, Dumas G, Dupont T, Lukaszewicz AC, Group TRS, Souilhi S, Henquell C, Venet F, Bonnet B, Souweine B.   +16 more
europepmc   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Explainable machine learning framework with Granger-based temporal predictive validation for monitoring fiscal risk in national health insurance expenditure. [PDF]

PLoS One
Lee G.
europepmc   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source