Results 171 to 180 of about 44,115,319 (295)

Associated-Factor Studies in Biomedical Research: Foundations, Limitations, and Criteria for Appropriate Use. [PDF]

Epidemiologia (Basel)
Vera-Ponce VJ, Ballena-Caicedo J.
europepmc   +1 more source

A Decision Rule to Minimize Daily Capital Charges in Forecasting Value-at-Risk [PDF]

Under the Basel II Accord, banks and other Authorized Deposit-taking Institutions (ADIs) have to communicate their daily risk estimates to the monetary authorities at the beginning of the trading day, using a variety of Value-at-Risk (VaR) models to ...
Michael McAleer, Juan-Ángel Jiménez-Martín, Teodosio Pérez-Amaral   +2 more
core  

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

American Society of Hematology 2026 guidelines for the diagnosis and management of severe and very severe acquired aplastic anemia. [PDF]

Blood Adv
Scheinberg P, O'Neal DA, Basquiera AL, Byrne MT, Calado R, Desai R, DeZern AE, Dufour C, Groarke EM, Han H, Hosokawa K, Kansal R, Kulasekararaj A, Mossad SB, Muus P, Patel B, Risitano AM, Schrezenmeier H, Sharma A, Shimamura A, Shimano KA, Tortosa F, Avila C, Ragusa M, Izcovich A, Neumann I.   +25 more
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Identification of recurrence risk factors and development of personalized follow-up strategies for esophageal squamous cell carcinoma patients after neoadjuvant therapy and surgery: a retrospective cohort study. [PDF]

J Thorac Dis
Cai Y, Wei N, Cai X, Ding J, Teng C, Chen L.   +5 more
europepmc   +1 more source

Tail Risk for Australian Emerging Market Entities [PDF]

Whilst the Australian economy is widely considered to have fared better than many of its global counterparts during the Global Financial Crisis, there was nonetheless extreme volatility experienced in Australian financial markets.
Akhmad R. Kramadibrata, David E Allen, Abhay Kumar Singh, R. J. Powell   +3 more
core  

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

New Strategies in Tuberculosis Prediction: TB-CAST, an Explainable Baseline Score for Two-Month Sputum Culture Positivity. [PDF]

Life (Basel)
Miulescu MA, Grecu VI, Streba L, Călărașu C, Rădulescu PM, Streba CT.   +5 more
europepmc   +1 more source