Results 171 to 180 of about 2,017,563 (356)
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source
Moment Methods for Exotic Volatility Derivatives [PDF]
The latest generation of volatility derivatives goes beyond variance and volatility swaps and probes our ability to price realized variance and sojourn times along bridges for the underlying stock price process.
Albanese, Claudio, Osseiran, Adel
core +1 more source
Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source
Double Variance Reduction: A Smoothing Trick for Composite Optimization Problems without First-Order Gradient [PDF]
arXivVariance reduction techniques are designed to decrease the sampling variance, thereby accelerating convergence rates of first-order (FO) and zeroth-order (ZO) optimization methods. However, in composite optimization problems, ZO methods encounter an additional variance called the coordinate-wise variance, which stems from the random gradient estimation.
arxiv
Generalized conditional spacings and their stochastic properties
AIMS MathematicsThis paper introduces the concept of generalized conditional spacings and establishes partial order relations between different generalized spacings. First, we derive the survival function of the generalized conditional spacings. Second, we construct the
Tie Li, Zhengcheng Zhang
doaj +1 more source
Advanced Science, EarlyView.MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun +13 more
wiley +1 more source
Ensayos Revista de Economía, 2011 The paper aimed at modelling the density of inflation based on time-varying conditional variance, skewness and kurtosis model developed by Leon, Rubio, and Serna (2005) who model higher-order moments as GARCH-type processes by applying a Gram-Charlier ...
Doaa Akl Ahmed
doaj
Fast estimation of Kendall's Tau and conditional Kendall's Tau matrices under structural assumptions
Dependence ModelingKendall’s tau and conditional Kendall’s tau matrices are multivariate (conditional) dependence measures between the components of a random vector. For large dimensions, available estimators are computationally expensive and can be improved by averaging ...
van der Spek Rutger, Derumigny Alexis
doaj +1 more source
Re-evaluating Hedging Performance [PDF]
Mixed results have been documented for the performance of hedging strategies using futures. This paper reinvestigates this issue using an extensive set of performance evaluation metrics across seven international markets.
Jim Hanly, John Cotter
core
Advanced Science, EarlyView.Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen +12 more
wiley +1 more source