Results 251 to 260 of about 1,581,275 (287)

Factors influencing unplanned readmissions after paediatric haematopoietic stem cell transplantation and effect on overall survival. [PDF]

Sci Rep
Pan X, Guo X, Mo L, Zhang S, Yao J, Ran X.   +5 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Extinction of Innate Floral Preferences in the Generalist Solitary Pollinator Eristalis tenax. [PDF]

J Chem Ecol
Rajan D, Mishra A, Sharan M, Gharpure G, Olsson S.   +4 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A pilot investigation of muscle conditioning as a tool to study neck proprioception and vestibular reweighting during head to trunk movement. [PDF]

Sci Rep
Polus B, Stylianou S, Harman S, Kumar DK, Watanabe N.   +4 more
europepmc   +1 more source

IV. A relation of the had condition of the mountains about the Tungarouse and Batavian Rivers, having their source from thence, occasioned by the earthquake between the 4th and 5th of January, 1699. Drawn up from the account given by the Tommagon Porbo Nata, (who hath been there) and sent to the Burgermaster Witsem, who communicated it to the R. Society of which he is a member. [PDF]

Tommagon Porbo Nata
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Neural correlates of human fear conditioning and sources of variability in 2199 individuals. [PDF]

Nat Commun
Radua J, Savage HS, Vilajosana E, Jamieson A, Abler B, Åhs F, Beckers T, Cardoner N, Cisler JM, Diniz JB, Bach DR, Elsenbruch S, Greening SG, Holt DJ, Kaczkurkin AN, Keil A, Kindt M, Koch K, LaBar KS, Lam CL, Larson CL, Lonsdorf TB, Merz CJ, McLaughlin KA, Neria Y, Pine DS, van Reekum CM, Shackman AJ, Soriano-Mas C, Spoormaker VI, Stout DM, Straube B, Straube T, Tuominen L, Visser RM, Ahumada L, Arolt V, Batistuzzo MC, Bazán PR, Biggs EE, Cano M, Chavarría-Elizondo P, Cooper SE, Dannlowski U, de la Peña-Arteaga V, DeCross SN, Domschke K, Ehlers MR, Graner JL, Hamm AO, Herrmann MJ, Huggins AA, Icenhour A, Juaneda-Seguí A, Junghoefer M, Kircher T, Koelkebeck K, Kuhn M, Labrenz F, Lissek SM, Lotze M, Lueken U, Margraf J, Martínez-Zalacaín I, Moeck R, Morriss J, Ortuño M, Pittig A, Porta-Casteras D, Richter J, Ridderbusch IC, Rief W, Roesmann K, Rosén J, Rußmann AN, Sjouwerman R, Spohrs J, Ströhle A, Suarez-Jimenez B, Ulrich M, Wittchen HU, Zhu X, Waller L, Walter H, Thompson PM, Bas-Hoogendam JM, Groenewold NA, J Stein D, Van der Wee NJ, Dunsmoor JE, Marquand AF, J Harrison B, Fullana MA.   +92 more
europepmc   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source