Results 91 to 100 of about 23,181,762 (302)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Russian economy: challenges and reaction
Путеводитель предпринимателяThe article examines and analyzes the problems and dynamics of economic growth in 2024 under the influence of external and internal factors and conditions, the dynamics of the key interest rate and inflation, and ways to reduce the volatility of the ...
L. A. Akhmetov, M. A. Bulavina
doaj +1 more source
Factors Influencing Production of Fusaristatin A in Fusarium graminearum
Metabolites, 2015 Fusarium graminearum is a ubiquitous plant pathogen, which is able to produce several bioactive secondary metabolites. Recently, the cyclic lipopeptide fusaristatin A was isolated from this species and the biosynthetic gene cluster identified ...
Anne Hegge +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Bratislava Law Review, 2018 This article focuses particularly on identifying the limits of the problematic aspects of the formulation of the contract proposal or contractual terms and conditions as a part of the tender documents in the context of compliance with the principles of ...
Peter Lukáčka, Peter Kubolek
doaj +1 more source
Consequences of Weyl Consistency Conditions
, 2013 The running of quantum field theories can be studied in detail with the use of a local renormalization group equation. The usual beta-function effects are easy to include, but by introducing spacetime-dependence of the various parameters of the theory ...
Grinstein, Benjamin +2 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Organizational and legal conditions for the creation of sports arbitration in Ukraine
Слобожанський науково-спортивний вісник, 2019 Purpose: to determine the organizational and managerial conditions for creating sports arbitration in Ukraine. Material & Methods: method of theoretical analysis and generalization of literary sources, which made it possible to determine the state of ...
Marina Sannikova
doaj +1 more source