Results 131 to 140 of about 341,651 (315)
CUTANEOUS HEAT AND COLD RECEPTORS WITH SLOWLY CONDUCTING (C) AFFERENT FIBRES [PDF]
, 1959 A. Iggo
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Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Zoological Results of the Third Tanganyika Expedition, conducted [PDF]
, 1910 William A. Cunnington, G. O. Sars
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Moral Values, A Study of the Principles of Conduct.
, 1918 Frank Chapman Sharp +1 more
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Physiological evidence of the fludity of the conducting substance in the pedel nerves of the slug—Ariolimax columbianus [PDF]
, 1904 Oliver Jenkins, A. J. Carlson
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