Results 41 to 50 of about 1,086,669 (193)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A review of conducting polymers in electrical contact applications

open access: yes, 2007
A review of recent developments in fretting studies in electrical contacts is presented, focusing on developments in conducting polymer surfaces. Fretting is known to be a major cause of contact deterioration and failure; commonly exhibited as the ...
Lam, Liza, McBride, J.W.
core   +1 more source

Poly(o-methoxyaniline) modified electrode for detection of lithium ions

open access: yesQuímica Nova, 2012
This paper reports the use of an electrode modified with poly(o-methoxyaniline) for detecting lithium ions. These ions are present in drugs used for treating bipolar disorder and that requires periodical monitoring of the concentration of lithium in ...
Cleber Antonio Lindino   +3 more
doaj   +1 more source

Recent developments in polyurethane-based conducting polymer composites

open access: yes, 2004
Polyurethane-based conducting composites with polyaniline, polythiophene or polypyrrole are in the class of modern macromolecular materials that combine the toughness and elasticity of polyurethane matrix with conductivity of intrinsically conducting ...
Pielichowski, Krzysztof   +1 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

The contact resistance force relationship of an intrinsically conducting polymer interface

open access: yes, 2006
Investigations on contact connector materials for different applications such as in the automotive industry have focused toward the increasing interest of using conducting polymers, as compared to conventional metallic contacts.
Swingler, Jonathan   +4 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Ferrocene-Functionalized 4-(2,5-Di(thiophen-2-yl)-1H-pyrrol-1-yl)aniline: A Novel Design in Conducting Polymer-Based Electrochemical Biosensors

open access: yesSensors, 2015
Herein, we report a novel ferrocenyldithiophosphonate functional conducting polymer and its use as an immobilization matrix in amperometric biosensor applications.
Rukiye Ayranci   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Enhanced Stability and Conductivity of (polyaniline/chitosan) Composites

open access: yesOrbital: The Electronic Journal of Chemistry, 2018
This study describes the synthesis of Pani-Chitosan soluble hybrid composite through an in situ polymerization of aniline in hydrochloride acid media in the presence of chitosan.
Fernando Ratuchne   +2 more
doaj   +3 more sources

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