Results 81 to 90 of about 316,529 (268)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Corrigendum: The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism

Frontiers in Physiology, 2022
Xin Liu, Xin Liu, Xin Liu, Chuan Qu, Chuan Qu, Chuan Qu, Shaobo Shi, Shaobo Shi, Shaobo Shi, Tianxin Ye, Tianxin Ye, Tianxin Ye, Linglin Wang, Linglin Wang, Linglin Wang, Steven Liu, Steven Liu, Steven Liu, Cui Zhang, Cui Zhang, Cui Zhang, Jinjun Liang, Jinjun Liang, Jinjun Liang, Dan Hu, Dan Hu, Dan Hu, Bo Yang, Bo Yang, Bo Yang   +29 more
doaj   +1 more source

COMPUESTO DE HIDROXIAPATITA-LIGNINA COMO ÓSEO-INTEGRADOR ENTRE TEJIDO ÓSEO E IMPLANTE METÁLICO: EVALUACIÓN MECÁNICA HYDROXYAPATITE-LIGNIN COMPOUND AS AN OSSEUS-INTEGRATOR BETWEEN BONE TISSUE AND A METALLIC IMPLANT: MECHANICAL EVALUATION

Revista U.D.C.A Actualidad & Divulgación Científica, 2009
En el estudio, se evaluó al compuesto de hidroxiapatita-lignina como óseo-integrador entre tejido óseo e implante metálico por prueba de tracción, considerándose oportuna la investigación por la necesidad de hallar un biomaterial que guíe o posea ...
Mastoby Martínez, Andrea Pacheco, Ricardo Della, Emily Correna, Liana Mesquita, Glaucia Oliveira, Sheila Bicalho   +6 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Experimental and Theoretical Investigation of Drying of Green Peas in a Fluidized Bed Dryer of Inert Particles Assisted by Infrared Heat Source [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2013
Drying of green peas in a Fluidized Bed Dryer (FBD) with inert particle, heated by combined sources of hot air and InfraRed (IR) radiation, has been experimentally and theoretically studied. For this purpose, an experimental set up was constructed.
Bijan Honarvar, Dariush Mowla, Ali Akbar Safekordi   +2 more
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source