Results 91 to 100 of about 856,405 (365)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Intraarticular Tramadol-Bupivacaine Combination Prolongs the Duration of Postoperative Analgesia After Outpatient Arthroscopic Knee Surgery [PDF]

, 2008
BACKGROUND: Intraarticular (IA) local anesthetics are often used for the management and prevention of pain after arthroscopic knee surgery. Recently, IA tramadol was also used for the management of these patients.
Baraka, Anis, El-Katib, Mohamad, Kassem, Rida, Maaliki, Hilal, Nahleh, Nezih, Struys, Michel, Zeidan, Ahed   +6 more
core   +2 more sources

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

FEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo, Yupeng Yin, Susu Guo, Xiaoyan Chen, Suyan Xie, Shiqin Chen, Yan Huang   +6 more
wiley   +1 more source

Multiple Instance Segmentation in Brachial Plexus Ultrasound Image Using BPMSegNet [PDF]

arXiv, 2020
The identification of nerve is difficult as structures of nerves are challenging to image and to detect in ultrasound images. Nevertheless, the nerve identification in ultrasound images is a crucial step to improve performance of regional anesthesia.
arxiv  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Analgesic efficacy of the external oblique intercostal fascial plane block on postoperative acute pain in laparoscopic sleeve gastrectomy: a randomized controlled trial [PDF]

Korean Journal of Anesthesiology
Background Laparoscopic sleeve gastrectomy (LSG) causes significant postoperative pain, necessitating effective multimodal analgesia strategies. This study evaluated the efficacy of the external oblique intercostal block (EOIB) in this context.
Elif Sarikaya Ozel, Cengiz Kaya, Esra Turunc, Yasemin B. Ustun, Halil Cebeci, Burhan Dost   +5 more
doaj   +1 more source

Maxillary nerve block: A comparison between the greater palatine canal and high tuberosity approaches. [PDF]

, 2018
Aim: Analgesia and anxiolysis during dental procedures are important for dental care and patient compliance. This study aims to compare two classical maxillary nerve block (MNB) techniques: the greater palatine canal (GPC) and the high tuberosity (HT ...
Bacci, C, Bartorelli, Lmg, Ferrario, S, Grossi, Gb, Menozzi, G, Sivolella, S, Zanette, G.   +6 more
core  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

COMBINED ANESTHESIA BY SEVOFLURANE AND FENTANYL IN ELDERLY PATIENTS WITH DIFFERENT REACTIVITY OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Кубанский научный медицинский вестник, 2018
Aim. To evaluate anesthesia according to the central hemodynamic, oxygen, acid-base, temperature homeostasis, neuromuscular conduction monitoring the depth of anesthesia and recovery postanesthesia consciousness.Materials and methods.
R. V. VEYLER
doaj   +1 more source

Effects of anesthesia on conventional and speckle tracking echocardiographic parameters in a mouse model of pressure overload [PDF]

, 2015
Genetically‑modified mice are widely applied in cardiovascular studies as model organisms. Echocardiography is a key tool for evaluating cardiac and hemodynamic functions in mice.
Cao, Ming, He, Wei, Manyande, Anne, Wang, Guan, Wang, Jinli, Wu, Xiaofen, Zhang, Cuntai, Zhang, Le   +7 more
core   +1 more source