Results 41 to 50 of about 148,827 (308)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Boosting electromagnetic wave absorption of Ti₃AlC₂ by improving effective electrical conductivity

Journal of Advanced Ceramics, 2023
Electromagnetic wave-absorbing (EMA) materials at high temperatures are limited by poor conduction loss (Lc). However, adding conductors simultaneously increases the conduction loss and interfacial polarization loss, leading to a conflict between ...
Kai-Yu Guo, Lin Chen, Guan-Jun Yang
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Nelson, C.P., Whittaker, John, Kumari, Meena, Folkersen, Lasse, Lasse Folkersen, Drenos, F., Drenos, Fotios, Kumari, M., Nelson, Christopher P, Amuzu, A., Mika Kivimaki, Nilesh J. Samani, Braund, P.S., Folkersen, L., Whittaker, J., Juan-Pablo Casas, John Whittaker, Eriksson, Per, Burton, P.R., Christopher P. Nelson, Meena Kumari, Zhang, H., Tom R. Gaunt, Debbie A. Lawlor, Casas, J.-P., Peter S. Braund, Adeniran, Ismail, Samani, Nilesh J, Sonia Shah, Samani, N.J., Antoinette Amuzu, Amuzu, Antoinette, Humphries, S.E., Zhang, Henggui, Henggui Zhang, Philippa J. Talmud, Day, I.N.M., Hancox, Jules C, Hancox, J.C., Tomaszewski, M., Hingorani, Aroon D, Burton, Paul R, Maciej Tomaszewski, Lawlor, D.A., Jules C. Hancox, Ian N.M. Day, Steve E. Humphries, Kivimaki, Mika, Kivimaki, M., Tobin, Martin D, Lawlor, Debbie A, Hingorani, A.D., Per Eriksson, Eriksson, P., Tomaszewski, Maciej, Peter W. Macfarlane, Humphries, Steve E, Shah, S., Ismail Adeniran, Day, Ian NM, Macfarlane, P.W., Martin D. Tobin, Paul R. Burton, Day, Ian N M, Gaunt, Tom R, Macfarlane, Peter W, Adeniran, I., Fotios Drenos, Shah, Sonia, Talmud, Philippa J, Gaunt, T.R., Tobin, M.D., Casas, Juan-Pablo, Talmud, P.J., Braund, Peter S, Tomaszewski, Maciej; id_orcid, Aroon D. Hingorani   +76 more
core   +1 more source

Third Quadrant Conduction Loss of 1.2-10 kV SiC MOSFETs: Impact of Gate Bias Control

, 2021
The third quadrant (3rd-quad) conduction of power MOSFETs involves competing current sharing between the metal-oxide-semiconductor (MOS) channel and the body diode controlled by the gate bias (VG).
Zhang, Yuhao, Lin, Xiang, Zhang, Ruizhe, Liu, Jingcun, Dong, Dong, Mocevic, Slavko   +5 more
core   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Influence of ear canal occlusion and air-conduction feedback on speech production in noise [PDF]

, 2014
Millions of workers are exposed to high noise levels on a daily basis. The primary concern for these individuals is the prevention of noise-induced hearing loss, which is typically accomplished by wearing of some type of personal hearing protector ...
Byrne, David
core  

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

A Novel 6500 V SiC Trench MOSFET with Integrated Unipolar Diode for Improved Third Quadrant and Switching Characteristics

Micromachines, 2023
A 6500 V SiC trench MOSFET with integrated unipolar diode (UD-MOS) is proposed to improve reverse conduction characteristics, suppress bipolar degradation, and reduce switching loss.
Hao Wu, Xuan Li, Xiaochuan Deng, Yangyang Wu, Jiawei Ding, Wensong Peng, Bo Zhang   +6 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source