Results 111 to 120 of about 145,387 (305)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Low heat conduction in white dwarf boundary layers?

, 2008
X-ray spectra of dwarf novae in quiescence observed by Chandra and XMM-Newton provide new information on the boundary layers of their accreting white dwarfs.
Asai, Asai, Belloni, Brandenburg, Chandran, E. Meyer-Hofmeister, Ettori, F. K. Liu, F. Meyer, Ghizzardi, Goldreich, Hartmann, Hirose, Jansen, Liu, Liu, Markevitch, Medvedev, Medvedev, Meyer, Meyer, Meyer, Meyer-Hofmeister, Meyer-Hofmeister, Mukai, Narayan, Narayan, Pandel, Pandel, Perna, Ramsay, Ramsay, Rechester, Sasonov, Sharma, Shmeleva, Strüder, Sutherland, Turner, V. Burwitz, van der Woerd, Vikhlinin, Voigt, Xiang, Zakamska   +44 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Adjustable High Current Low Profile Sandwich Inductor Using Nanocrystalline Flake Ribbon Core

IEEE Open Journal of Power Electronics
Compact and high current inductors determine the power density and efficiency of voltage regulators (VRs) for computing ICs. Conventional moulding structures using powder cores and gapped ferrite cores are reaching the limits of size miniaturization.
Xinru Li, Mingxiao Li, Luke Shillaber, Borong Hu, Zhichao Luo, Chaoqiang Jiang, Teng Long   +6 more
doaj   +1 more source

Fast Collisionless Reconnection Condition and Self-Organization of Solar Coronal Heating

, 2007
I propose that solar coronal heating is a self-regulating process that keeps the coronal plasma roughly marginally collisionless. The self-regulating mechanism is based on the interplay of two effects.
Brown J. C., Bulanov S. V., Dmitri A. Uzdensky, Kulsrud R. M., Landi E., Lee L. C., Masuda S., Parker E. N., Scholer M., Thompson C., Tsuneta S., Ugai M., Uzdensky D. A., Uzdensky D. A.   +13 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

High Power Density IGBT Loss Calculation Model and Analysis

Energies
This paper presents the establishment of an accurate loss model for high-power-density IGBT modules used in electric vehicles, leveraging the thermal simulation capabilities of the power electronics simulation software PLECS 4.1.
Feng Wang, Yifan Song, Wang Dou, Zhaolei Zheng, Zhuangzhuang Li, Biao Li, Jun Liu   +6 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Thermal Instability of Solar Prominence Threads

, 2011
The fine structure of solar prominences and filaments appears as thin and long threads in high-resolution images. In H-alpha observations of filaments, some threads can be observed for only 5 - 20 minutes before they seem to fade and eventually disappear,
Arregui, Ballester, Berger ., Braginskii, Chae, Chae, Engvold, Engvold, Heinzel, Heyvaerts, J. L. Ballester, Klimchuk, Lin, Lin, Lin, M. Goossens, Priest, R. Soler, Rempel, Soler, Soler, Soler, Spitzer   +22 more
core   +1 more source