Results 111 to 120 of about 146,399 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Generation of radiative knots in a randomly pulsed protostellar jet I. Dynamics and energetics

, 2009
HH objects are characterized by a complex knotty morphology detected mainly along the axis of protostellar jets in a wide range of bands. Evidence of interactions between knots formed in different epochs have been found, suggesting that jets may result ...
Bonito, Bonito, Bonito, Borkowski, Caratti o Garatti, Colella, Cowie, Dalton, Eislöffel, Eislöffel, F. Favata, Favata, Favata, Fridlund, Fridlund, Fryxell, G. Peres, Giuliani, Hartigan, J. Eislöffel, M. Miceli, MacNeice, Mewe, Orlando, Podio, R. Bonito, Raga, Raga, Raymond, Reipurth, Reipurth, Roberts, S. Orlando, Vitorino, Yirak   +34 more
core   +2 more sources

Adjustable High Current Low Profile Sandwich Inductor Using Nanocrystalline Flake Ribbon Core

IEEE Open Journal of Power Electronics
Compact and high current inductors determine the power density and efficiency of voltage regulators (VRs) for computing ICs. Conventional moulding structures using powder cores and gapped ferrite cores are reaching the limits of size miniaturization.
Xinru Li, Mingxiao Li, Luke Shillaber, Borong Hu, Zhichao Luo, Chaoqiang Jiang, Teng Long   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

High Power Density IGBT Loss Calculation Model and Analysis

Energies
This paper presents the establishment of an accurate loss model for high-power-density IGBT modules used in electric vehicles, leveraging the thermal simulation capabilities of the power electronics simulation software PLECS 4.1.
Feng Wang, Yifan Song, Wang Dou, Zhaolei Zheng, Zhuangzhuang Li, Biao Li, Jun Liu   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Regeneration experiments below 10K in a regenerative-cycle cryocooler [PDF]

, 1983
At temperatures below 10K, regenerative cycle cryocoolers are limited by regeneration losses in the helium working fluid which result from the decreasing heat capacity of the regenerating material and the increasing density of helium.
Paulson, D. N., Sager, R. E.
core   +1 more source

Non-equilibrium of Ionization and the Detection of Hot Plasma in Nanoflare-heated Coronal Loops

, 2008
Impulsive nanoflares are expected to transiently heat the plasma confined in coronal loops to temperatures of the order of 10 MK. Such hot plasma is hardly detected in quiet and active regions, outside flares.
Fabio Reale, Klimchuk J. A., Mewe R., Orlando S., Reale F., Salvatore Orlando, Serio S.   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source