Results 221 to 230 of about 25,749,367 (326)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Phylogenesis of the Conduction System of the Heart

Journal of Arrhythmia, 2008
Kouichi Taniguchi, MD
doaj   +1 more source

Comparative analysis of conduction system pacing learning curves for atrioventricular block: A single-operator experience. [PDF]

Heart Rhythm O2
Pestrea C, Cicala E, Sisea-Polexa S, Dobre M, Enache R, Ortan F.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19. [PDF]

JCI Insight
Ashok D, Liu T, Nakanishi-Koakutsu M, Criscione J, Prakash M, Tensfeldt A, Kim B, Ho B, Chow J, Craney M, Ranek MJ, Lin BL, Papanicolaou K, Sidor A, Foster DB, Cho HC, Pekosz A, Villano J, Kim DH, O'Rourke B.   +19 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Riding the Highs and Lows of the Conduction System Pacing Wave-Our Experience. [PDF]

J Cardiovasc Dev Dis
Teo HK, Chua YY, Tay JCK, Pung X, Ong JWS, Loo GJM, Lim ETS, Ho KL, Chong DTT, Ching CK.   +9 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Electrophysiological characteristics of Purkinje potentials and the conduction system in premature ventricular contractions triggering ventricular fibrillation after myocardial infarction. [PDF]

Europace
Hayashi T, Komatsu Y, Kowase S, Fukamizu S, Nagashima K, Takahashi M, Mori H, Tao S, Yamamoto S, Onishi Y, Yagishita A, Ohashi J, Fukunaga M, Mizukami A, Inaba O, Kasai Y, Kitai T, Yamashita K, Tokudome D, Hashiguchi N, Nakamura T, Sato K, Sahara N, Minami K, Ugata Y, Asano T, Kato R, Sasano T, Fujita H.   +28 more
europepmc   +1 more source