Results 41 to 50 of about 61,518 (262)
Effect of neurodynamic mobilization techniques in patients with diabetic neuropathy
Human Movement, 2023 Purpose Neurodynamic mobilization is a set of passive or active movements aimed at restoring the neural system’s ability to bear the normal compressive, friction, and tensile stresses encountered in daily life.
Ahmed Magdy Alshimy +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Impact of height on sensory nerve conduction
National Journal of Physiology, Pharmacy and Pharmacology, 2017 Background: Change in height of the limb not only increases the length of nerve but also causes gradual tapering of nerve with decrease in fiber diameter and myelination.
Yogita Dilip Sulaxane +1 more
doaj +1 more source
THE FACTORS THAT INFLUENCE ON NERVE CONDUCTION IN DIABETIC PATIENTS [PDF]
Basrah Journal of Surgery, 2015 The alteration in nerve conduction is considered one of the important complaints of patients who are suffering from diabetes mellitus nowadays. Therefore, we conduct this study which aimed to evaluate the nerve conduction velocity and amplitude in ...
Abdul Al-Razzaq N Khudair +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Prevalence of carpal tunnel syndrome in patients with long-term type 2 diabetes mellitus
Heliyon, 2022 Generally, Carpal tunnel syndrome (CTS) is more common in diabetes mellitus (DM), especially in subjects with coexisting diabetic polyneuropathy (DPN) and/or long-term DM.
Defu Dong, Hongwei Liu
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source