Results 41 to 50 of about 12,678 (260)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Coupled Fixed Point Theorems under Weak Contractions

open access: yesDiscrete Dynamics in Nature and Society, 2012
Cho et al. [Comput. Math. Appl. 61(2011), 1254–1260] studied common fixed point theorems on cone metric spaces by using the concept of c-distance. In this paper, we prove some coupled fixed point theorems in ordered cone metric spaces by using the ...
Y. J. Cho   +3 more
doaj   +1 more source

Cone Metric Spaces over Topological Modules and Fixed Point Theorems for Lipschitz Mappings

open access: yesMathematics, 2020
In this paper, we introduce the concept of cone metric space over a topological left module and we establish some coincidence and common fixed point theorems for self-mappings satisfying a condition of Lipschitz type.
Adrian Nicolae Branga, Ion Marian Olaru
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Common Fixed Points of Two Mappings regarding a Generalized c-Distance over a Banach Algebra

open access: yesJournal of Function Spaces, 2021
In this article, applying the concept of a generalized c-distance in cone b-metric spaces over Banach algebra with a nonnormal solid cone therein, we establish several common fixed point theorems for two noncontinuous mappings satisfying the Han-Xu-type ...
Ladan Aryanpour   +2 more
doaj   +1 more source

Kähler–Einstein metrics: From cones to cusps [PDF]

open access: yesJournal für die reine und angewandte Mathematik (Crelles Journal), 2018
Abstract In this note, we prove that on a compact Kähler manifold X \hskip-0.569055pt{X}\hskip-0.569055pt
openaire   +3 more sources

Normal Cones and Thompson Metric [PDF]

open access: yes, 2014
The aim of this paper is to study the basic properties of the Thompson metric $d_T$ in the general case of a real linear space $X$ ordered by a cone $K$. We show that $d_T$ has monotonicity properties which make it compatible with the linear structure. We also prove several convexity properties of $d_T$ and some results concerning the topology of $d_T$,
Cobzaş, Ştefan, Rus, Mircea Dan
openaire   +2 more sources

Drawing Cone Spherical Metrics via Strebel Differentials [PDF]

open access: yesInternational Mathematics Research Notices, 2018
Abstract Cone spherical metrics are conformal metrics with constant curvature one and finitely many conical singularities on compact Riemann surfaces. By using Strebel differentials as a bridge, we construct a new class of cone spherical metrics on compact Riemann surfaces by drawing on the surfaces some class of connected metric ribbon ...
Song, Jijian   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Quasicone Metric Spaces and Generalizations of Caristi Kirk's Theorem

open access: yesFixed Point Theory and Applications, 2009
Cone-valued lower semicontinuous maps are used to generalize Cristi-Kirik's fixed point theorem to Cone metric spaces. The cone under consideration is assumed to be strongly minihedral and normal.
Karapinar Erdal, Abdeljawad Thabet
doaj  

Home - About - Disclaimer - Privacy