Results 151 to 160 of about 88,835 (298)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

A Covalent 3D CNT@rGO Nano‐Hybrid for High‐Efficiency Conductivity in Lithium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
A facile one‐step CVD strategy achieves high‐yield (7692.31%) growth of CNTs on rGO, forming a covalently bonded 3D CNT@rGO hybrid. This structure enables multidirectional conductive networks in LiFePO4 cathodes, delivering superior rate performance, high ICE (99.88%), and 96.32% capacity retention after 300 cycles at 1 C.
Junwen Tang   +10 more
wiley   +1 more source

Determination of undrained strengths by cone penetration tests.

open access: yes, 2016
Calculations have been presented for the loads on a cone penetrometer in a cohesive material, with the validity of the calculations being limited at present to a penetrometer near the surface of a soil. The undrained strength of a cohesive soil could therefore be back-analysed from measurements of loads on cone penetrometers.
Houlsby, G, Wroth, C
openaire   +2 more sources

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon   +10 more
wiley   +1 more source

Enhancing the Ultrasonic Welding of Wood Using 3D Printed Lignin Energy Directors

open access: yesAdvanced Science, EarlyView.
Sustainable manufacturing for lightweight structures using ecofriendly materials will be key to reducing material consumption and lowering carbon footprints. Here, an approach is presented to weld wood using ultrasonic vibrations with material at the joint interface to direct energy.
Muhamad Amani   +6 more
wiley   +1 more source

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