Results 171 to 180 of about 153,276 (314)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Guided by Energy, Ethics and Empathy. [PDF]

Nordisk Alkohol Nark
Hellman M.
europepmc   +1 more source

Reflections on the evolution of a masters programme in instrumentation and control delivered by distance learning. [PDF]

, 2018
Bevan, G., Holmes Smith, A.S., McKenna, P., Niculita, O., Wallace, P.A.   +4 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

History—Pre-Confederation

Canadian Jewish Studies, 2000

doaj   +1 more source

Lessons Learned from Implementing Injury and Illness Surveillance in Professional Football: Introducing a New Implementation Framework. [PDF]

Sports Med
Tabben M, Hassanmirzaei B, Singh G, Miladi R, Chaabane M, McCourt P, Serner A, Clarsen B, Ellouze Z, Mokrani M, Whiteley R, D'Hooghe P, Cardinale M, Schumacher YO, Bahr R.   +14 more
europepmc   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Confederate Women

The Journal of American History, 1976
Jacquelyn Dowd Hall, Bell Irvin Wiley
openaire   +2 more sources

Manufacturing Productivity in Sweden: an International Perspective Since 1960 [PDF]

International Productivity Monitor, 2005
Daniel Lind
doaj  

Prophylactic Lymphedema Surgery During Soft Tissue Sarcoma Resection: Surgical Technique Step by Step. [PDF]

Plast Reconstr Surg Glob Open
Torrano L, Zamora-Alarcón P, Masia J, Barrantes-Verdoi S, D'Guilio G, Fernández-Garrido M.   +5 more
europepmc   +1 more source